{"doi":"10.1093/jb/mvr053","title":"Encountering unpredicted off-target effects of pharmacological inhibitors","abstract":null,"journal":"Journal of Biochemistry","year":2011,"id":655775,"datarank":0.4493598410330987,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.0,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":548023,"name":"K. Miyazawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Encountering unpredicted off-target effects of pharmacological inhibitors","abstract":"With the emergence of chemical biology, the use of pharmacological inhibitors in biological research has been expanding. SP600125 is a low-molecular weight compound that has been widely used to inhibit c-Jun-N-terminal kinase (JNK). A recent publication by Tanemura et al. (J. Biochem. 145:345-354, 2009) indicated that SP600125 also inhibits phosphatidylinositol 3-kinase (PI3K) in an isoform-selective fashion: it efficiently inhibited the delta isoform of p110 catalytic subunit (p110δ), which is primarily expressed in leucocytes, but neither of the ubiquitously expressed isoforms, p110α and p110γ. Here, I discuss what we learn from such unpredicted off-target effects of pharmacological inhibitors.","is_dataset_classified":null,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21558088","pmcid":null,"openalex_id":"https://openalex.org/W2158117691","authors":[],"funders":[],"total_grants":0,"fwci":0.787,"citation_percentile":0.72843194,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":2},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2021,"count":3},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/jb/article-pdf/150/1/1/2557251/mvr053.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jb/mvr053","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21558088","host_type":"repository"},{"url":"http://jb.oxfordjournals.org/cgi/content/short/mvr053v1","host_type":"repository"}],"fields_of_study":["Chronic Myeloid Leukemia Treatments","Melanoma and MAPK Pathways","Chronic Lymphocytic Leukemia Research","Animals","Anthracenes","Cell Degranulation","Cytokines","Mast Cells","Phosphoinositide-3 Kinase Inhibitors","Receptors, IgE","Signal Transduction"],"mesh_terms":["Phosphoinositide-3 Kinase Inhibitors","Animals","Anthracenes","Mast Cells","Signal Transduction","Cell Degranulation","Cytokines","Receptors, IgE"],"keywords":["Gene isoform","P110α","Kinase","Protein subunit","Phosphatidylinositol","Chemistry","Isozyme","Biochemistry","Cell biology","Biology","Enzyme","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T18:54:23.532843Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}