{"doi":"10.1093/jb/mvn011","title":"Biological Function of Fucosylation in Cancer Biology","abstract":null,"journal":"Journal of Biochemistry","year":2007,"id":605938,"datarank":0.8968328647351684,"base_score":5.978885764901122,"endowment":5.978885764901122,"self_citation_contribution":0.8968328647351684,"citation_network_contribution":0.0,"self_endowment_contribution":0.8968328647351684,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":394,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1555322,"name":"K. Moriwaki","orcid":null,"position":1,"is_corresponding":false},{"id":1555323,"name":"T. Nakagawa","orcid":null,"position":2,"is_corresponding":false},{"id":1555321,"name":"E. Miyoshi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biological Function of Fucosylation in Cancer Biology","abstract":"Fucosylation is one of the most common modifications involving oligosaccharides on glycoproteins or glycolipids. Fucosylation comprises the attachment of a fucose residue to N-glycans, O-glycans and glycolipids. O-Fucosylation, which is a special type of fucosylation, is very important for Notch signalling. The regulatory mechanisms for fucosylation are complicated. Many kinds of fucosyltransferases, the GDP-fucose synthesis pathway and GDP-fucose transporter are involved in the regulation of fucosylation. Increased levels of fucosylation have been reported in a number of pathological conditions, including inflammation and cancer. Therefore, certain types of fucosylated glycoproteins such as AFP-L3 or several kinds of antibodies, which recognize fucosylated oligosaccharides such as sialyl Lewis a/x, have been used as tumour markers. Furthermore, fucosylation of glycoproteins regulates the biological functions of adhesion molecules and growth factor receptors. Changes in fucosylation could provide a novel strategy for cancer therapy. In this review, the biological significance of and regulatory pathway for fucosylation have been described.","is_dataset_classified":null,"base_score":5.978885764901122,"endowment":5.978885764901122,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18218651","pmcid":null,"openalex_id":"https://openalex.org/W2132240438","authors":[],"funders":[],"total_grants":0,"fwci":3.8977,"citation_percentile":0.9454117,"influential_citations":0,"citation_trend":[{"year":2012,"count":22},{"year":2013,"count":22},{"year":2014,"count":24},{"year":2015,"count":24},{"year":2016,"count":30},{"year":2017,"count":24},{"year":2018,"count":27},{"year":2019,"count":27},{"year":2020,"count":22},{"year":2021,"count":25},{"year":2022,"count":26},{"year":2023,"count":26},{"year":2024,"count":18},{"year":2025,"count":17},{"year":2026,"count":8}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/jb/article-pdf/143/6/725/6440354/mvn011.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jb/mvn011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18218651","host_type":"repository"},{"url":"http://jb.oxfordjournals.org/cgi/content/short/mvn011v1","host_type":"repository"},{"url":"http://jb.oxfordjournals.org/cgi/content/short/mvn011v2","host_type":"repository"},{"url":"http://jb.oxfordjournals.org/cgi/content/short/mvn011v3","host_type":"repository"}],"fields_of_study":["Glycosylation and Glycoproteins Research","Monoclonal and Polyclonal Antibodies Research","Galectins and Cancer Biology","Animals","Fucose","Fucosyltransferases","Humans","Neoplasms"],"mesh_terms":["Animals","Fucose","Fucosyltransferases","Humans","Neoplasms"],"keywords":["Fucosylation","Fucosyltransferase","Fucose","Glycan","Glycoprotein","Biochemistry","Glycolipid","Chemistry","Biology","Cell biology","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Decent work and economic growth"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:33:11.973916Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}