{"doi":"10.1093/jb/mvm090","title":"Phosphorylation of the C-terminal Domain of RNA Polymerase II Plays Central Roles in the Integrated Events of Eucaryotic Gene Expression","abstract":null,"journal":"The Journal of Biochemistry","year":2007,"id":589508,"datarank":7.160352960563788,"base_score":5.117993812416755,"endowment":5.117993812416755,"self_citation_contribution":0.7676990718625134,"citation_network_contribution":6.3926538887012745,"self_endowment_contribution":0.7676990718625134,"citer_contribution":6.3926538887012745,"corpus_percentile":null,"corpus_rank":null,"citation_count":166,"citer_count":159,"citers_with_citation_signal":136,"citers_with_endowment":136,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1508280,"name":"Yoshiaki Ohkuma","orcid":null,"position":1,"is_corresponding":false},{"id":1508279,"name":"Yutaka Hirose","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Phosphorylation of the C-terminal Domain of RNA Polymerase II Plays Central Roles in the Integrated Events of Eucaryotic Gene Expression","abstract":"RNA polymerase II (Pol II) is the only polymerase to possess heptapeptide repeats in the C-terminal domain (CTD) of its large subunit. During transcription, CTD phopshorylation occurs and is maintained from initiation to termination. To date, among the three known CTD kinases possessing CDK-cyclin pairs, TFIIH is the only one that forms a preinitiation complex. The Mediator complex plays essential roles in transcription initiation and during the transition from initiation to elongation by transmitting signals from transcriptional activators to Pol II. P-TEFb specifically plays a role in transcription elongation. TFIIH and mediator phosphorylate serine 5 (Ser5) of the CTD heptapeptide repeat sequence, whereas P-TEFb phosphorylates serine 2 (Ser2). Recently, it has become clear that CTD phosphorylation is not only essential for transcription, but also as a platform for RNA processing and chromatin regulation. In this review, we discuss the central role of Pol II phosphorylation in these nuclear events.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17405796","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/jb/article-pdf/141/5/601/13311531/mvm090.pdf","host_type":"publisher"}],"fields_of_study":["Adaptor Proteins, Signal Transducing","Humans","Models, Biological","Models, Molecular","Nuclear Proteins","Nucleotidyltransferases","Phosphorylation","Protein Conformation","Protein Structure, Tertiary","RNA Polymerase II","RNA Precursors","RNA Processing, Post-Transcriptional","RNA Splicing","Transcription, Genetic","mRNA Guanylyltransferases"],"mesh_terms":["Humans","Nucleotidyltransferases","RNA Polymerase II","Adaptor Proteins, Signal Transducing","Nuclear Proteins","RNA Precursors","Transcription, Genetic","RNA Processing, Post-Transcriptional","RNA Splicing","Protein Conformation","Protein Structure, Tertiary","Phosphorylation","Models, Biological","Models, Molecular","mRNA Guanylyltransferases"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-23T20:15:34.142895Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}