{"doi":"10.1093/jb/mvad066","title":"Curcumin analog GO-Y030 inhibits tumor metastasis and glycolysis","abstract":"Tumor metastasis is one of the worst prognostic features of cancer. Although metastasis is a major cause of cancer-related deaths, an effective treatment has not yet been established. Here, we explore the antitumor effects of GO-Y030, a curcumin analog, via various mechanisms using a mouse model. GO-Y030 treatment of B16-F10 melanoma cells inhibited TGF-β expression and glycolysis. The invasion assay results showed almost complete invasion inhibition following GO-Y030 treatment. Mouse experiments demonstrated that GO-Y030 administration inhibited lung tumor metastasis without affecting vascular endothelial cells. Consistent with this result, GO-Y030 treatment led to the downregulation of MMP2 and VEGFα, inhibiting tumor invasion and metastasis. The silencing of eIF4B, a downstream molecule of S6, attenuated MMP2 expression. Our study demonstrates the novel efficacy of GO-Y030 in inhibiting tumor metastasis by regulating metastasis-associated gene expression via inhibiting dual access, glycolytic and TGF-β pathways.","journal":"The Journal of Biochemistry","year":2023,"id":370331,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1072879,"name":"Hirofumi Miyazaki","orcid":"0000-0003-2695-7479","position":1,"is_corresponding":false},{"id":399119,"name":"Taishi Komori","orcid":"0000-0002-7412-4503","position":2,"is_corresponding":false},{"id":1129462,"name":"Shion Osana","orcid":"0000-0001-8998-252X","position":3,"is_corresponding":false},{"id":700205,"name":"Hiroyuki Shibata","orcid":"0000-0003-3581-3506","position":4,"is_corresponding":false},{"id":700202,"name":"Yuji Owada","orcid":"0000-0002-5109-0531","position":5,"is_corresponding":false},{"id":700196,"name":"Shuhei Kobayashi","orcid":"0000-0002-1019-8669","position":6,"is_corresponding":false},{"id":230163,"name":"Takashi Maruyama","orcid":"0000-0003-0820-3219","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:15:37.094100Z","pmid":"37656908","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}