{"doi":"10.1093/jas/sky404.818","title":"121 A controlled heat stress during late gestation affects thermoregulation, productive performance and metabolic profiles of primiparous sows.","abstract":null,"journal":"Journal of Animal Science","year":2018,"id":690097,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1194509,"name":"W Zheng","orcid":null,"position":1,"is_corresponding":false},{"id":1802875,"name":"Y Xue","orcid":null,"position":2,"is_corresponding":false},{"id":1802876,"name":"H Guo","orcid":null,"position":3,"is_corresponding":false},{"id":1802877,"name":"W Yao","orcid":null,"position":4,"is_corresponding":false},{"id":1802874,"name":"J He","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"121 A controlled heat stress during late gestation affects thermoregulation, productive performance and metabolic profiles of primiparous sows.","abstract":"Heat stress (HS) alters metabolic parameters and reduces productive performance in pregnant sows. However, the impact of HS on metabolomic profiles associated with host metabolism is not completely understood. The objective of this study was to investigate thermoregulation, productive performance and especially metabolic responses in sows exposed to HS during late gestation. Twelve first-parity Landrace × Large White F1 sows were assigned into two environmental treatments containing thermoneutral (TN) (18–22℃; n=6) and HS (28–32℃; n=6) conditions from 85 d of gestation until farrowing. Rectal temperature (RT), respiration rates (RR), and surface temperature (ST) were determined every 4 h from 0800h to 2000h. Farrowing and litter Data, as well as feed duration, were monitored to assess sows’ productive performance. Blood biochemical parameters and urinary metabolomic profiles were measured at d107 of gestation to analyze the host metabolic responses. As expected, HS increased RT, RR and ST (P<0.001). Gestation length, total born, born alive and litter body weight (BW) at birth were not affected (P>0.10), whereas duration of parturition was prolonged during the delivery in HS group (P<0.05). Feed duration was increased due to both HS and time (P<0.001), which corresponded with significant changes in serum ghrelin and gastric inhibitory polypeptide (GIP) (P<0.01). Moreover, serum ACTH, cortisol, T3, T4, insulin, creatinine and BUN were increased (P<0.01) while IGF-1 was decreased (P<0.001) due to HS. Plasma HDL, LDL and NEFA were elevated by HS (P<0.05). Additionally, HS elevated (VIP>1, log2fold change>0.585, and P<0.05) the relative concentrations of 5-aminovaleric acid, β-alanine, cysteine, isoleucine, glyceric acid, erythronic acid, mannitol, erythritol, 2-methyl-1,3-butanediol, and pantothenic acid, which mainly affected the pantothenate and CoA biosynthesis, β-alanine metabolism, and glycerolipid metabolism. In summary, the controlled HS during late gestation elevated thermal responses, reduced productive performance, and most importantly affected metabolism of first-parity pregnant sows.","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":"PMC6285251","openalex_id":"https://openalex.org/W2904327887","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.15043491,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":6}],"oa_status":"closed","license":"https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model","oa_locations":[{"url":"http://academic.oup.com/jas/article-pdf/96/suppl_3/372/27055651/sky404.818.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jas/sky404.818","host_type":"journal"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6285251","host_type":"repository"}],"fields_of_study":["Effects of Environmental Stressors on Livestock","Adipose Tissue and Metabolism","Biology","Agricultural and Food Sciences"],"mesh_terms":[],"keywords":["NEFA","Gestation","Internal medicine","Endocrinology","Litter","Thermoregulation","Animal science","Creatinine","Biology","Insulin","Pregnancy","Medicine","Metabolism","Heat stress","Sow","Productive performance"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.24494292.v1","title":"Additional file 1 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24494292","title":"Additional file 1 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24494476.v1","title":"Additional file 2 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.24494476","title":"Additional file 2 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26634888.v1","title":"Additional file 3 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26634888","title":"Additional file 3 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26634891.v1","title":"Additional file 4 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26634891","title":"Additional file 4 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26634933.v1","title":"Additional file 18 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634918","title":"Additional file 13 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634903.v1","title":"Additional file 8 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634915.v1","title":"Additional file 12 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634894.v1","title":"Additional file 5 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634897","title":"Additional file 6 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634909.v1","title":"Additional file 10 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634912","title":"Additional file 11 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634918.v1","title":"Additional file 13 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634900.v1","title":"Additional file 7 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634903","title":"Additional file 8 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634930","title":"Additional file 17 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634921.v1","title":"Additional file 14 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634924.v1","title":"Additional file 15 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634909","title":"Additional file 10 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634924","title":"Additional file 15 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.26634921","title":"Additional file 14 of Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits","publisher":"figshare","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-22T22:30:59.740032Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}