{"doi":"10.1093/jamiaopen/ooaf110","title":"Workflows to automate covariate-adaptive randomization in REDCap via data entry triggers","abstract":"Objective: Covariate-adaptive randomization algorithms (CARAs) can reduce covariate imbalance in randomized controlled trials (RCTs), but a lack of integration into Research Electronic Data Capture (REDCap) has limited their use. We developed a software pipeline to seamlessly integrate CARAs into REDCap as part of the all2GETHER study, a 2-armed RCT concerning HIV prevention. Materials and Methods: Leveraging REDCap's Data Entry Trigger and a separate server, we implemented software in PHP and R to automate randomizations for all2GETHER. Randomizations were triggered by saving a specific REDCap form and were automatically communicated to unblinded study personnel. Results: = 0.003 for continuous variables and risk differences <2.4% for categorical/binary variables. Conclusions: Our pipeline proved effective at reducing covariate imbalance with minimal additional effort for study personnel. Discussion: This pipeline is reproducible and could be used by other RCTs that collect data via REDCap.","journal":"JAMIA Open","year":2025,"id":576552,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1485420,"name":"Marc O Broxton","orcid":null,"position":1,"is_corresponding":false},{"id":394676,"name":"Luke V. Rasmussen","orcid":"0000-0002-4497-8049","position":2,"is_corresponding":false},{"id":577130,"name":"Gregory Swann","orcid":"0000-0001-5901-4608","position":3,"is_corresponding":false},{"id":355568,"name":"Michael E. Newcomb","orcid":"0000-0002-8431-2946","position":4,"is_corresponding":false},{"id":446991,"name":"Jody D. Ciolino","orcid":"0000-0002-9060-5657","position":5,"is_corresponding":false},{"id":848059,"name":"Jacob M. Schauer","orcid":"0000-0002-9041-7082","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T02:57:56.636458Z","pmid":"41041624","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}