{"doi":"10.1093/jamia/ocae201","title":"An evaluation of the <i>All of Us</i> Research Program database to examine cumulative stress","abstract":"OBJECTIVES: To evaluate the NIH All of Us Research Program database as a potential data source for studying allostatic load and stress among adults in the United States (US). MATERIALS AND METHODS: We evaluated the All of Us database to determine sample size significance for original-10 allostatic load biomarkers, Allostatic Load Index-5 (ALI-5), Allostatic Load Five, and Cohen's Perceived Stress Scale (PSS). We conducted a priori, post hoc, and sensitivity power analyses to determine sample sizes for conducting null hypothesis significance tests. RESULTS: The maximum number of responses available for each measure is 21 participants for the original-10 allostatic load biomarkers, 150 for the ALI-5, 22 476 for Allostatic Load Five, and n = 90 583 for the PSS. DISCUSSION: The NIH All of Us Research Program is well-suited for studying allostatic load using the Allostatic Load Five and psychological stress using PSS. CONCLUSION: Improving biomarker data collection in All of Us will facilitate more nuanced examinations of allostatic load among US adults.","journal":"Journal of the American Medical Informatics Association","year":2024,"id":459862,"datarank":0.3109612182807842,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.06954553141566913,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.06954553141566913,"corpus_percentile":45.99675098630773,"corpus_rank":6982,"citation_count":4,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.929,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":332697,"name":"Demetrius A. Abshire","orcid":"0000-0002-4234-128X","position":1,"is_corresponding":false},{"id":1286916,"name":"Trey L. DeJong","orcid":"0000-0001-5286-5493","position":2,"is_corresponding":false},{"id":1094417,"name":"Jason T. Carbone","orcid":"0000-0001-5096-5212","position":3,"is_corresponding":false},{"id":1286915,"name":"Shawna Beese","orcid":"0000-0002-1815-6594","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:03:59.428859Z","pmid":"39058629","pmcid":"PMC11631057","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}