{"doi":"10.1093/jac/dkr291","title":"Transmission dynamics of the M184V drug resistance mutation in primary HIV infection","abstract":null,"journal":"Journal of Antimicrobial Chemotherapy","year":2011,"id":599946,"datarank":0.5742962094733643,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.0,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1537813,"name":"D. Moisi","orcid":null,"position":1,"is_corresponding":false},{"id":1386818,"name":"M. Oliveira","orcid":"0000-0002-6195-3716","position":2,"is_corresponding":false},{"id":1537814,"name":"T. D. Toni","orcid":null,"position":3,"is_corresponding":false},{"id":1537815,"name":"B. G. Brenner","orcid":null,"position":4,"is_corresponding":false},{"id":1537812,"name":"M. A. Wainberg","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Transmission dynamics of the M184V drug resistance mutation in primary HIV infection","abstract":"OBJECTIVES: M184V in HIV-1 reverse transcriptase is among the most common mutations in patients failing antiretroviral therapy but is found only rarely in cases of transmitted drug resistance. METHODS: To investigate this apparent paradox, we developed an allele-specific real-time PCR (AS-PCR) assay to determine the transmission of M184V in newly infected individuals. RESULTS: M184V transmission may occur to a greater extent than previously thought. Persistence of M184V may commonly involve linkage to other drug resistance mutations. The presence of M184V as a single substitution in newly infected individuals was shown to wane over time, as a likely consequence of reversion and overgrowth by more fit wild-type viruses. CONCLUSIONS: The M184V mutation can be documented in newly infected individuals, and the alternative hypothesis that this substitution might impact on the ability of HIV to be transmitted is unfounded.","is_dataset_classified":null,"base_score":3.828641396489095,"endowment":3.828641396489095,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21750100","pmcid":null,"openalex_id":"https://openalex.org/W2149330759","authors":[],"funders":[],"total_grants":0,"fwci":1.5028,"citation_percentile":0.80502877,"influential_citations":0,"citation_trend":[{"year":2012,"count":5},{"year":2013,"count":3},{"year":2014,"count":6},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":4},{"year":2018,"count":5},{"year":2019,"count":1},{"year":2020,"count":3},{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/jac/article-pdf/66/10/2346/2181087/dkr291.pdf","host_type":"journal"},{"url":"https://academic.oup.com/jac/article-pdf/66/10/2346/2181087/dkr291.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/jac/article-pdf/66/10/2346/2181087/dkr291.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/jac/dkr291","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21750100","host_type":"repository"},{"url":"http://jac.oxfordjournals.org/cgi/content/short/66/10/2346","host_type":"repository"},{"url":"http://jac.oxfordjournals.org/cgi/content/short/dkr291v1","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","HIV/AIDS drug development and treatment","Biological Research and Disease Studies"],"mesh_terms":["Genotype","Humans","Molecular Sequence Data","Mutation","HIV-1","HIV Infections","Reverse Transcriptase Inhibitors","Anti-HIV Agents","Drug Resistance, Viral","HIV Reverse Transcriptase","Real-Time Polymerase Chain Reaction"],"keywords":["Resistance mutation","Reverse transcriptase","Reversion","Virology","Mutation","Drug resistance","Transmission (telecommunications)","Biology","Human immunodeficiency virus (HIV)","Genetics","Polymerase chain reaction","Phenotype","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T11:45:36.355993Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}