{"doi":"10.1093/jac/dkad341","title":"Renal outcomes in adults with HBV, HIV and HBV/HIV coinfection after 3 years of antiviral therapy in urban Tanzania","abstract":"BACKGROUND: An enhanced understanding of renal outcomes in persons with chronic HBV, HIV, and HBV/HIV coinfection is needed to mitigate chronic kidney disease in regions where HBV and HIV are endemic. OBJECTIVES: To investigate changes in estimated glomerular filtration rate (eGFR) in adults with HBV, HIV or HBV/HIV enrolled in a 3 year prospective cohort study of liver outcomes in Dar es Salaam, Tanzania and initiated on antiviral therapy. METHODS: We compared eGFR between and within groups over time using mixed-effects models. RESULTS: Four hundred and ninety-nine participants were included in the analysis (HBV: 164; HIV: 271; HBV/HIV: 64). Mean baseline eGFRs were 106.88, 106.03 and 107.18 mL/min/1.73 m2, respectively. From baseline to Year 3, mean eGFR declined by 4.3 mL/min/1.73 m2 (95% CI -9.3 to 0.7) and 3.7 (-7.8 to 0.5) in participants with HBV and HIV, respectively, and increased by 5.1 (-4.7 to 14.9) in those with HBV/HIV. In multivariable models, participants with HBV had lower eGFRs compared with those with HIV or HBV/HIV and, after adjusting for HBV DNA level and hepatitis B e antigen (HBeAg) status, significantly lower eGFRs than those with HBV/HIV at all follow-up visits. CONCLUSIONS: In this Tanzanian cohort, coinfection with HBV/HIV did not appear to exacerbate renal dysfunction compared with those with either infection alone. Although overall changes in eGFR were small, persons with HBV experienced lower eGFRs throughout follow-up despite their younger age and similar baseline values. Longer-term studies are needed to evaluate continuing changes in eGFR and contributions from infection duration and other comorbidities.","journal":"Journal of Antimicrobial Chemotherapy","year":2023,"id":386988,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1156240,"name":"Beatrice Christian","orcid":null,"position":1,"is_corresponding":false},{"id":742480,"name":"Adovich S. Rivera","orcid":"0000-0003-2533-0818","position":2,"is_corresponding":false},{"id":1156241,"name":"Emanuel Fabian","orcid":null,"position":3,"is_corresponding":false},{"id":1156242,"name":"Irene Macha","orcid":null,"position":4,"is_corresponding":false},{"id":880149,"name":"Eric Aris","orcid":null,"position":5,"is_corresponding":false},{"id":1156243,"name":"Shida Mpangala","orcid":null,"position":6,"is_corresponding":false},{"id":296593,"name":"Nzovu Ulenga","orcid":null,"position":7,"is_corresponding":false},{"id":468891,"name":"Ferdinand Mugusi","orcid":"0000-0001-7479-4913","position":8,"is_corresponding":false},{"id":12095,"name":"Robert L. Murphy","orcid":"0000-0003-3936-2052","position":9,"is_corresponding":false},{"id":411273,"name":"Claudia Hawkins","orcid":"0000-0001-7228-6317","position":10,"is_corresponding":false},{"id":660318,"name":"En‐Ling Wu","orcid":"0000-0002-5679-6277","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T01:18:04.706547Z","pmid":"37935111","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}