{"doi":"10.1093/intimm/dxg109","title":"OcaB regulates transitional B cell selection","abstract":null,"journal":"International Immunology","year":2003,"id":602738,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1545976,"name":"M. Jankovic","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"OcaB regulates transitional B cell selection","abstract":"OcaB, also known as Bob-1 or Obf-1, is a transcriptional co-activator which regulates Igkappa gene transcription, recombination and receptor editing; it is required for normal development of transitional B cells and for germinal center formation. Here we report that abnormal B cell development in OcaB(-/-) mice results in a skewed Igkappa repertoire including anti-DNA antibodies, suggesting that OcaB is essential for antibody repertoire selection. To determine whether OcaB is required for BCR-mediated B cell selection, we introduced a pre-recombined alpha hen egg lysozyme (HEL) Ig transgene into OcaB(-/-) mice. We find that in OcaB(-/-) mice expressing transgenic alphaHEL Ig bone marrow B cell development is normal up to the immature B cell stage, but fails to progress to the transitional B cell stage. We conclude that OcaB is required for normal selection of the antibody repertoire in developing B cells.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12917262","pmcid":null,"openalex_id":"https://openalex.org/W2100299646","authors":[],"funders":[],"total_grants":0,"fwci":0.468,"citation_percentile":0.60669708,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":3},{"year":2014,"count":3},{"year":2015,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":4}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://academic.oup.com/intimm/article-pdf/15/9/1099/2228091/dxg109.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/intimm/dxg109","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12917262","host_type":"repository"}],"fields_of_study":["T-cell and B-cell Immunology","Immunotherapy and Immune Responses","Immune Cell Function and Interaction","Animals","Antibodies, Antinuclear","Antibodies, Monoclonal","Autoantibodies","B-Lymphocytes","Bone Marrow Cells","Cell Cycle","Cells, Cultured","Enzyme-Linked Immunosorbent Assay","Flow Cytometry","Gene Expression Regulation","Genes, Immunoglobulin","Immune Tolerance","Immunoglobulin M","Immunoglobulin kappa-Chains","Immunoglobulins","Mice","Mice, Inbred C57BL","Mice, Knockout","Mice, Transgenic","Muramidase","Polymerase Chain Reaction","Receptors, Antigen, B-Cell","Spleen","Trans-Activators"],"mesh_terms":["Animals","Antibodies, Monoclonal","Antibodies, Antinuclear","Autoantibodies","B-Lymphocytes","Bone Marrow Cells","Cell Cycle","Cells, Cultured","Enzyme-Linked Immunosorbent Assay","Flow Cytometry","Gene Expression Regulation","Genes, Immunoglobulin","Immunoglobulin M","Immune Tolerance","Immunoglobulins","Immunoglobulin kappa-Chains","Mice, Inbred C57BL","Mice, Transgenic","Muramidase","Receptors, Antigen, B-Cell","Spleen","Trans-Activators","Polymerase Chain Reaction","Mice, Knockout","Mice"],"keywords":["Germinal center","B cell","Biology","Antibody","Transgene","Antibody Repertoire","Affinity maturation","B-cell receptor","Repertoire","Molecular biology","breakpoint cluster region","Gene","Cell biology","Transitional Cell","Genetics","Cancer"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T20:10:38.132978Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}