{"doi":"10.1093/infdis/jiy293","title":"Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates","abstract":null,"journal":"The Journal of Infectious Diseases","year":2018,"id":606361,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1556638,"name":"Joan B Geisbert","orcid":null,"position":1,"is_corresponding":false},{"id":480386,"name":"Demetrius Matassov","orcid":"0000-0002-5441-2882","position":2,"is_corresponding":false},{"id":1556641,"name":"Krystle N Agans","orcid":null,"position":3,"is_corresponding":false},{"id":124945,"name":"Viktoriya Borisevich","orcid":null,"position":4,"is_corresponding":false},{"id":1556645,"name":"Robert W Cross","orcid":null,"position":5,"is_corresponding":false},{"id":1556646,"name":"Daniel J Deer","orcid":null,"position":6,"is_corresponding":false},{"id":1556647,"name":"Karla A Fenton","orcid":null,"position":7,"is_corresponding":false},{"id":1556648,"name":"John H Eldridge","orcid":null,"position":8,"is_corresponding":false},{"id":1556649,"name":"Chad E Mire","orcid":null,"position":9,"is_corresponding":false},{"id":1556650,"name":"Thomas W Geisbert","orcid":null,"position":10,"is_corresponding":false},{"id":242843,"name":"Courtney Woolsey","orcid":"0000-0003-3389-0137","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates","abstract":"A recombinant vesicular stomatitis virus (rVSV) expressing the Marburg virus (MARV) Musoke variant glycoprotein fully protects macaques against 2 MARV variants and Ravn virus as a preventive vaccine and MARV variant Musoke as a postexposure treatment. To evaluate postexposure efficacy against the most pathogenic MARV variant, Angola, we engineered rVSVs expressing homologous Angola glycoprotein. Macaques were challenged with high or low doses of variant Angola and treated 20-30 minutes after exposure. A total of 25% and 60%-75% of treated macaques survived the high-dose and low-dose challenges, respectively. The more rapid disease progression of variant Angola versus variant Musoke may account for the incomplete protection observed.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29939296","pmcid":"PMC6249565","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"U19 AI109711","title":null},{"funder_name":"National Institutes of Health","grant_id":"1U19AI109711-01","title":"BSL4 Evaluation Core"},{"funder_name":"National Institutes of Health","grant_id":"5U19AI109711-04","title":"Advancement of Treatments for Ebola and Marburg Virus Infections"}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"CC BY NC ND","oa_locations":[{"url":"http://academic.oup.com/jid/article-pdf/218/suppl_5/S582/26689532/jiy293.pdf","host_type":"publisher"},{"url":"https://europepmc.org/articles/PMC6249565","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6249565?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1093/infdis/jiy293","host_type":""},{"url":"https://academic.oup.com/jid/article-pdf/218/suppl_5/S582/26689532/jiy293.pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/29939296","host_type":""},{"url":"http://dx.doi.org/10.1093/infdis/jiy293","host_type":""},{"url":"https://dx.doi.org/10.1093/infdis/jiy293","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Macaca mulatta","Marburg Virus Disease","Vaccines, Synthetic","Viral Vaccines","Genetic Vectors","Female","Male","Marburgvirus","Vesicular stomatitis Indiana virus"],"keywords":["Male","Vaccines, Synthetic","Genetic Vectors","Supplement Articles","Viral Vaccines","Macaca mulatta","Vesicular stomatitis Indiana virus","Marburgvirus","Animals","Female","Marburg Virus Disease"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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