{"doi":"10.1093/infdis/jix570","title":"High Plasmodium Infection Rate and Reduced Bed Net Efficacy in Multiple Insecticide-Resistant Malaria Vectors in Kinshasa, Democratic Republic of Congo","abstract":null,"journal":"The Journal of Infectious Diseases","year":2018,"id":681232,"datarank":0.6573039952010823,"base_score":4.382026634673881,"endowment":4.382026634673881,"self_citation_contribution":0.6573039952010823,"citation_network_contribution":0.0,"self_endowment_contribution":0.6573039952010823,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":79,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":8,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1779884,"name":"Francis Watsenga","orcid":null,"position":1,"is_corresponding":false},{"id":1618084,"name":"Helen Irving","orcid":null,"position":2,"is_corresponding":false},{"id":1779885,"name":"Seth R Irish","orcid":null,"position":3,"is_corresponding":false},{"id":1779886,"name":"Charles S Wondji","orcid":null,"position":4,"is_corresponding":false},{"id":1779883,"name":"Jacob M Riveron","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"High Plasmodium Infection Rate and Reduced Bed Net Efficacy in Multiple Insecticide-Resistant Malaria Vectors in Kinshasa, Democratic Republic of Congo","abstract":"Accounting for approximately 11% of all malaria cases, the Democratic Republic of the Congo (DRC) is central to malaria elimination efforts. To support vector control interventions in DRC, we characterized the dynamics and impact of insecticide resistance in major malaria vectors in 2015. High Plasmodium infection rates were recorded in Anopheles gambiae and Anopheles funestus, with Plasmodium falciparum predominant over Plasmodium malariae. Both mosquito species exhibited high and multiple resistance to major public health insecticide classes. The extremely high resistance to permethrin and DDT (dichlorodiphenyltrichloroethane) in An. gambiae (low mortalities after 6 hours exposure) is worrisome, and is supported by a reduced insecticidal effect of bed nets against both mosquito species in laboratory tests. Metabolic and target site insensitivity mechanisms are driving this resistance in An. gambiae, but only the former was observed in An. funestus. These findings highlight the urgent need for actions to prolong the effectiveness of insecticide-based interventions in DRC.","is_dataset_classified":null,"base_score":4.382026634673881,"endowment":4.382026634673881,"datacite_reuse_total":8,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29087484","pmcid":"PMC5853898","openalex_id":"https://openalex.org/W2766484195","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"101893/Z/13/Z","title":null},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Wellcome Trust","grant_id":"101893","title":"Tackling insecticide resistance in the major African malaria vector Anopheles funestus: developing new molecular diagnostic tools, understanding the evolution of resistance and its impact on control interventions."},{"funder_name":"Wellcome Trust","grant_id":"","title":null},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":5,"fwci":8.5707,"citation_percentile":0.98081374,"influential_citations":0,"citation_trend":[{"year":2018,"count":7},{"year":2019,"count":16},{"year":2020,"count":13},{"year":2021,"count":9},{"year":2022,"count":9},{"year":2023,"count":10},{"year":2024,"count":6},{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://academic.oup.com/jid/article-pdf/217/2/320/24262971/jix570.pdf","host_type":"journal"},{"url":"https://academic.oup.com/jid/article-pdf/217/2/320/24262971/jix570.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/jid/article-pdf/217/2/320/24262971/jix570.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/infdis/jix570","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29087484","host_type":"repository"},{"url":"https://archive.lstmed.ac.uk/7813/1/Journal_of_infectious_diseases_High%20Plasmodium%20infection%20rate.pdf","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5853898","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5853898","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5853898?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1093/infdis/jix570","host_type":""},{"url":"https://archive.lstmed.ac.uk/7813/6/j_inf_dis_217_3_320-328_2018.pdf","host_type":""},{"url":"https://dx.doi.org/10.1093/infdis/jix570","host_type":""}],"fields_of_study":["Malaria Research and Control","Mosquito-borne diseases and control","Insect Pest Control Strategies","03 medical and health sciences","0302 clinical medicine","Animals","Anopheles","DDT","Democratic Republic of the Congo","Disease Transmission, Infectious","Female","Insecticide Resistance","Insecticide-Treated Bednets","Insecticides","Malaria","Male","Mosquito Control","Mosquito Vectors","Permethrin","Plasmodium","Sensitivity and Specificity"],"mesh_terms":["Mosquito Vectors","Animals","Anopheles","DDT","Female","Insecticide Resistance","Insecticides","Malaria","Male","Mosquito Control","Plasmodium","Sensitivity and Specificity","Democratic Republic of the Congo","Disease Transmission, Infectious","Permethrin","Insecticide-Treated Bednets"],"keywords":["Malaria","Anopheles gambiae","Plasmodium falciparum","Vector (molecular biology)","Biology","Bed nets","Anopheles","Permethrin","Plasmodium malariae","Plasmodium (life cycle)","Mosquito control","Insecticide resistance","Toxicology","Immunology","Pesticide","Parasite hosting","Ecology","Plasmodium vivax","Democratic Republic Of Congo","Male","Insecticides","Plasmodium","Mosquito Vectors","Sensitivity and Specificity","DDT","Major Articles and Brief Reports","qx_600","Disease Transmission, Infectious","Animals","Insecticide-Treated Bednets","wa_30","wc_750","qx_510","qx_135","Democratic Republic of the Congo","Female"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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