{"doi":"10.1093/infdis/jix230","title":"Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1","abstract":null,"journal":"The Journal of Infectious Diseases","year":2017,"id":672140,"datarank":0.7193685818395114,"base_score":4.795790545596741,"endowment":4.795790545596741,"self_citation_contribution":0.7193685818395114,"citation_network_contribution":0.0,"self_endowment_contribution":0.7193685818395114,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":120,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1756069,"name":"Azizath Moussiliou","orcid":null,"position":1,"is_corresponding":false},{"id":260442,"name":"Thomas Lavstsen","orcid":"0000-0002-3044-4249","position":2,"is_corresponding":false},{"id":623680,"name":"Claire Kamaliddin","orcid":"0000-0001-8198-6235","position":3,"is_corresponding":false},{"id":577417,"name":"Anja T. R. Jensen","orcid":"0000-0002-4004-7554","position":4,"is_corresponding":false},{"id":1756071,"name":"Atikatou Mama","orcid":null,"position":5,"is_corresponding":false},{"id":772860,"name":"Rachida Tahar","orcid":"0000-0003-1799-231X","position":6,"is_corresponding":false},{"id":729008,"name":"Christian W. Wang","orcid":"0000-0003-3140-6989","position":7,"is_corresponding":false},{"id":1073038,"name":"Jakob S. Jespersen","orcid":"0000-0002-4930-5900","position":8,"is_corresponding":false},{"id":1756072,"name":"Jules M. Alao","orcid":null,"position":9,"is_corresponding":false},{"id":1756073,"name":"Benoit Gamain","orcid":null,"position":10,"is_corresponding":false},{"id":677857,"name":"Thor G. Theander","orcid":"0000-0002-3509-7514","position":11,"is_corresponding":false},{"id":598356,"name":"Philippe Deloron","orcid":"0000-0003-4705-2484","position":12,"is_corresponding":false},{"id":598355,"name":"Nicaise Tuikue Ndam","orcid":"0000-0003-2646-2513","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1","abstract":"<h4>Background</h4>Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1 (ICAM-1), and endothelial protein C receptor (EPCR); however, cytoadhesion patterns typical for pediatric malaria syndromes and the associated PfEMP1 members are still undefined.<h4>Methods</h4>In a cohort of 94 hospitalized children with malaria, we characterized the binding properties of IE collected on admission, and var gene transcription using quantitative polymerase chain reaction.<h4>Results</h4>IE from patients with cerebral malaria were more likely to bind EPCR and ICAM-1 than IE from children with uncomplicated malaria (P = .007). The level of transcripts encoding CIDRα1.4 and CIDRα1.5 domain subclasses was higher in patients with severe disease (P < .05). IE populations exhibiting binding to all 3 receptors had higher levels of transcripts encoding PfEMP1 with CIDRα1.4 and Duffy binding-like (DBL)-β3 domains than parasites, which only bound CD36.<h4>Conclusions</h4>These results underpin the significance of EPCR binding in pediatric malaria patients that require hospital admission, and support the notion that complementary receptor interactions of EPCR binding PfEMP1with ICAM-1 amplifies development of severe malaria symptoms.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28863469","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Novo Nordisk Fonden","grant_id":"NNF16OC0022298","title":null},{"funder_name":"Lundbeck Foundation","grant_id":"R180-2014-3098","title":null},{"funder_name":"Novo Nordisk Fonden","grant_id":"NNF13OC0006249","title":null},{"funder_name":"Lundbeck Foundation","grant_id":"R77-2010-7185","title":null},{"funder_name":"Lundbeck Foundation","grant_id":"R140-2013-13448","title":null}],"total_grants":5,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/jid/article-pdf/215/12/1918/17944266/jix230.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/jid/article-pdf/215/12/1918/17944266/jix230.pdf","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Endothelial Cells","Humans","Plasmodium falciparum","Malaria, Cerebral","Malaria, Falciparum","Intercellular Adhesion Molecule-1","Receptors, Cell Surface","Protozoan Proteins","Antigens, CD","Cell Adhesion","Transcription, Genetic","Protein Binding","Child, Preschool","Infant","Endothelial Protein C Receptor"],"keywords":["Plasmodium falciparum","Cerebral malaria","ICAM-1","Pfemp1","Epcr"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T06:44:54.222561Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}