{"doi":"10.1093/infdis/jit614","title":"In Vivo Evaluation of Antibiotic Activity Against Mycobacterium abscessus","abstract":null,"journal":"The Journal of Infectious Diseases","year":2014,"id":690067,"datarank":0.7143260902196635,"base_score":4.762173934797756,"endowment":4.762173934797756,"self_citation_contribution":0.7143260902196635,"citation_network_contribution":0.0,"self_endowment_contribution":0.7143260902196635,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":116,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108178,"name":"Emmanuelle Cambau","orcid":null,"position":1,"is_corresponding":false},{"id":1802789,"name":"Romain Roth dit Bettoni","orcid":null,"position":2,"is_corresponding":false},{"id":1802105,"name":"Jean-Louis Gaillard","orcid":null,"position":3,"is_corresponding":false},{"id":398098,"name":"Vincent Jarlier","orcid":"0000-0003-0957-0002","position":4,"is_corresponding":false},{"id":1802790,"name":"Chantal Truffot","orcid":null,"position":5,"is_corresponding":false},{"id":1639578,"name":"Nicolas Veziris","orcid":null,"position":6,"is_corresponding":false},{"id":1802788,"name":"Isabelle Lerat","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"In Vivo Evaluation of Antibiotic Activity Against Mycobacterium abscessus","abstract":"BACKGROUND: The prognosis of Mycobacterium abscessus infections is poor due to the lack of effective drug treatment. The objective of this study was to set up an animal model suitable to test antibiotic activity against M. abscessus. METHODS: The following mouse strains were evaluated: Swiss, BALB/c, C57BL/6, nude, beige, A/J, and GKO. Antibiotic activity was tested for clarithromycin, amikacin, cefoxitin, tigecycline, and bedaquiline (TMC207). Finally, we evaluated the 3-drug combination clarithromycin, cefoxitin, and amikacin. RESULTS: Nude and GKO mice fulfilled criteria for the model but only nude mice offered sufficient availability for large therapeutic experiments. Among the 3 drugs usually combined for treatment of M. abscessus infection, cefoxitin was the most active because it improved survival and reduced bacillary loads in spleen whereas clarithromycin and amikacin prevented death but had little impact on bacillary loads. The triple-drug combination was not more active than cefoxitin alone. Tigecycline displayed bactericidal activity whereas bedaquiline was almost inactive. CONCLUSIONS: Nude mice are an adequate model for in vivo chemotherapy studies. Among tested drugs, cefoxitin and tigecycline showed promising in vivo activity against M. abscessus. The best drug combination remains to be determined.","is_dataset_classified":null,"base_score":4.762173934797756,"endowment":4.762173934797756,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24253289","pmcid":null,"openalex_id":"https://openalex.org/W2125725259","authors":[],"funders":[],"total_grants":0,"fwci":4.0773,"citation_percentile":0.94501996,"influential_citations":0,"citation_trend":[{"year":2014,"count":5},{"year":2015,"count":9},{"year":2016,"count":7},{"year":2017,"count":8},{"year":2018,"count":13},{"year":2019,"count":9},{"year":2020,"count":19},{"year":2021,"count":9},{"year":2022,"count":11},{"year":2023,"count":8},{"year":2024,"count":8},{"year":2025,"count":6},{"year":2026,"count":4}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://academic.oup.com/jid/article-pdf/209/6/905/17410500/jit614.pdf","host_type":"journal"},{"url":"https://academic.oup.com/jid/article-pdf/209/6/905/17410500/jit614.pdf","host_type":"publisher"},{"url":"http://academic.oup.com/jid/article-pdf/209/6/905/17410500/jit614.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/infdis/jit614","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24253289","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1023.6871","host_type":""}],"fields_of_study":["Mycobacterium research and diagnosis","Diphtheria, Corynebacterium, and Tetanus","Tuberculosis Research and Epidemiology","Animals","Anti-Bacterial Agents","Colony Count, Microbial","Diarylquinolines","Disease Models, Animal","Female","Kidney","Lung","Male","Mice","Mice, Inbred C57BL","Mice, Nude","Microbial Sensitivity Tests","Minocycline","Mycobacterium","Mycobacterium Infections","Spleen","Statistics, Nonparametric","Tigecycline"],"mesh_terms":["Tigecycline","Animals","Anti-Bacterial Agents","Disease Models, Animal","Female","Kidney","Lung","Male","Mice, Inbred C57BL","Mice, Nude","Microbial Sensitivity Tests","Minocycline","Mycobacterium","Mycobacterium Infections","Spleen","Colony Count, Microbial","Statistics, Nonparametric","Mice","Diarylquinolines"],"keywords":["Mycobacterium abscessus","Antibiotics","In vivo","Microbiology","Mycobacterium","Medicine","Nontuberculous mycobacteria","Biology","Pathology","Biotechnology","Tuberculosis","Nude mouse","Murine model","Cefoxitin","amikacin","Clarithromycin","Cystic Fibrosis","Tigecycline","Bedaquiline","Tmc207"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.13115219.v1","title":"Additional file 1 of The synergetic effect of Imipenem-clarithromycin combination in the Mycobacteroides abscessus complex","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.13115219","title":"Additional file 1 of The synergetic effect of Imipenem-clarithromycin combination in the Mycobacteroides abscessus complex","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-22T21:56:03.034846Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}