{"doi":"10.1093/infdis/jiaf526","title":"Epstein-Barr Virus Antibody Response Patterns in Endemic and Nonendemic Cases of Nasopharyngeal Carcinoma","abstract":"Epstein-Barr virus (EBV) causes most nasopharyngeal carcinoma (NPC), a malignancy endemic in certain regions, presenting with nonspecific symptoms and lacking a robust minimally invasive biomarker. To assess previously developed multiplex Luminex assay EBV antibody signatures in a nonendemic population, we analyzed and compared 98 NPC sera and 142 matched controls from the nonendemic Head and Neck 5000 clinical cohort against an endemic Taiwan case-control cohort. All models, except the 2-antibody IgA panel, performed similarly, achieving 90%-99% accuracy in identifying EBV-positive NPC. Our results showed that EBV antibody panels can accurately define EBV-positive NPC regardless of endemicity.","journal":"The Journal of Infectious Diseases","year":2025,"id":547613,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9627,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1439975,"name":"Aisha Babi","orcid":"0000-0002-2726-6955","position":1,"is_corresponding":false},{"id":914368,"name":"Julia Simon","orcid":"0000-0003-1432-2767","position":2,"is_corresponding":false},{"id":390102,"name":"Tim Waterboer","orcid":"0000-0002-0616-6963","position":3,"is_corresponding":false},{"id":1111636,"name":"Wan‐Lun Hsu","orcid":"0000-0002-7271-6070","position":4,"is_corresponding":false},{"id":317484,"name":"Chien‐Jen Chen","orcid":"0000-0002-6996-9069","position":5,"is_corresponding":false},{"id":317483,"name":"Kelly J. Yu","orcid":"0000-0003-3832-6586","position":6,"is_corresponding":false},{"id":261927,"name":"Miranda Pring","orcid":"0000-0003-4658-5772","position":7,"is_corresponding":false},{"id":729999,"name":"Katrina Hurley","orcid":"0000-0002-8079-5258","position":8,"is_corresponding":false},{"id":265756,"name":"Allan Hildesheim","orcid":"0000-0003-0257-2363","position":9,"is_corresponding":false},{"id":291440,"name":"Zhiwei Liu","orcid":"0000-0002-0136-651X","position":10,"is_corresponding":false},{"id":549896,"name":"Ilona Argirion","orcid":"0000-0002-4925-5296","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:53:41.314800Z","pmid":"41077708","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}