{"doi":"10.1093/infdis/jiaf453","title":"HIV and Syphilis Coinfection in Pregnancy and Adverse Birth Outcomes in Uganda","abstract":"BACKGROUND: Despite increasing global syphilis incidence, little is known about the combined impact of maternal HIV and syphilis coinfection. We evaluated effects of HIV/syphilis coinfection in pregnancy on birth outcomes. METHODS: We conducted 2 prospective birth cohort studies in Uganda from 2017 to 2023. Our primary outcome was birthweight. Our secondary outcome was a composite adverse birth outcome (birthweight <2.5 kg, stillbirth, early neonatal death, or 5-min APGAR<7). We compared outcomes by HIV and Treponema pallidum particle agglutination assay (TPPA) seropositivity and fitted multivariable regression models. RESULTS: Treponema pallidum particle agglutination assay seroprevalence was 12% (118/967); 19% (94/483) among WHIV and 5% (24/484) among women without HIV. Only 48% of TPPA-seropositive women reported syphilis testing during antenatal care. Stillbirth and early neonatal death were higher among TPPA seropositive (12%, 15/118) than seronegative (4%, 32/849) participants. Low birthweight was associated with HIV seropositivity (-0.1 kg, 95% CI -0.15, -0.04), younger maternal age (0.01 kg per year, 95% CI 0.01, 0.02), and lower gestational age (0.07 kg per week, 95% CI 0.06, 0.09) but not TPPA serostatus. The composite outcome was associated with lower maternal and gestational age. CONCLUSIONS: We report high TPPA seroprevalence, low syphilis testing rates, and associations with adverse birth outcomes, emphasizing the need to improve prenatal syphilis testing and treatment.","journal":"The Journal of Infectious Diseases","year":2025,"id":573768,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9159,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":698527,"name":"Timothy Mwanje Kintu","orcid":"0000-0002-5513-5899","position":1,"is_corresponding":false},{"id":1279720,"name":"Onesmus Byamukama","orcid":"0009-0006-1910-9761","position":2,"is_corresponding":false},{"id":263592,"name":"Ingrid V. Bassett","orcid":"0000-0001-6920-6080","position":3,"is_corresponding":false},{"id":69650,"name":"Mark J. Siedner","orcid":"0000-0003-3506-842X","position":4,"is_corresponding":false},{"id":1480931,"name":"Anacret Byamukama","orcid":"0000-0002-9270-5838","position":5,"is_corresponding":false},{"id":1128662,"name":"Edna Tindimwebwa","orcid":"0000-0003-4255-2818","position":6,"is_corresponding":false},{"id":768013,"name":"Pooja Chitneni","orcid":"0000-0002-5648-3852","position":7,"is_corresponding":false},{"id":454687,"name":"Julian Adong","orcid":"0000-0001-9314-5257","position":8,"is_corresponding":false},{"id":348460,"name":"Elias Kumbakumba","orcid":"0000-0001-7206-0609","position":9,"is_corresponding":false},{"id":443435,"name":"Stephen B. Asiimwe","orcid":"0000-0003-3705-5163","position":10,"is_corresponding":false},{"id":484676,"name":"Joseph Ngonzi","orcid":"0000-0001-5253-9516","position":11,"is_corresponding":false},{"id":243045,"name":"Lisa M. Bebell","orcid":"0000-0003-0077-6522","position":12,"is_corresponding":false},{"id":647363,"name":"Mehal Churiwal","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:57:36.753600Z","pmid":"40884500","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}