{"doi":"10.1093/infdis/jiaf139","title":"Noninvasive Monitoring of Humoral Immune Responses in Men With Acute <i>Chlamydia trachomatis</i> Urethral Infection Using First-Catch Urine","abstract":"We investigated the relationship between Chlamydia trachomatis load and anti-chlamydial antibody using first-catch urine from 108 men with nongonococcal urethritis. Men who reported prior chlamydia had elevated anti-chlamydial IgA and lower loads, but load and antibody were not correlated. Load positively correlated with anti-chlamydial IgA only in men who did not self-report prior chlamydia and with anti-chlamydial IgG regardless of infection history. Overall, we document genotype-specific differences in C. trachomatis load, clarify that partial immunity associated with repeat infections is not antibody mediated, and demonstrate a method to monitor humoral immune responses to C. trachomatis in men using noninvasively collected urine.","journal":"The Journal of Infectious Diseases","year":2025,"id":563080,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":728763,"name":"Caleb M. Ardizzone","orcid":"0000-0002-7915-4437","position":1,"is_corresponding":false},{"id":411365,"name":"Stephen J. Jordan","orcid":"0000-0003-4063-2566","position":2,"is_corresponding":false},{"id":441972,"name":"James A. Williams","orcid":"0000-0003-4998-6571","position":3,"is_corresponding":false},{"id":441973,"name":"Aaron Ermel","orcid":"0000-0002-1075-0126","position":4,"is_corresponding":false},{"id":1465420,"name":"Waleed M Alrebdi","orcid":"0009-0002-3134-3869","position":5,"is_corresponding":false},{"id":794141,"name":"Teresa A. Batteiger","orcid":"0000-0002-5097-1425","position":6,"is_corresponding":false},{"id":441971,"name":"Evelyn Toh","orcid":"0000-0003-2932-4060","position":7,"is_corresponding":false},{"id":779511,"name":"David E. Nelson","orcid":"0000-0001-9325-7208","position":8,"is_corresponding":false},{"id":1465419,"name":"Jenna Ryan","orcid":"0000-0003-4679-8284","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T02:56:09.638214Z","pmid":"40091619","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}