{"doi":"10.1093/infdis/jiaf080","title":"Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria","abstract":"Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.","journal":"The Journal of Infectious Diseases","year":2025,"id":562253,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1092097,"name":"Caroline Kazinga","orcid":null,"position":1,"is_corresponding":false},{"id":1146820,"name":"Giselle Lima-Cooper","orcid":"0000-0001-5168-9125","position":2,"is_corresponding":false},{"id":920007,"name":"Claire Liepmann","orcid":null,"position":3,"is_corresponding":false},{"id":855426,"name":"Michael Goings","orcid":null,"position":4,"is_corresponding":false},{"id":633192,"name":"Olivia J. Bednarski","orcid":"0000-0003-3029-8461","position":5,"is_corresponding":false},{"id":899526,"name":"Marco Abreu","orcid":"0000-0002-5659-1255","position":6,"is_corresponding":false},{"id":388337,"name":"Tae‐Hwi Schwantes‐An","orcid":"0000-0001-6387-0095","position":7,"is_corresponding":false},{"id":409952,"name":"Anthony Batte","orcid":"0000-0001-7463-5277","position":8,"is_corresponding":false},{"id":269837,"name":"Robert O. Opoka","orcid":"0000-0003-3240-2058","position":9,"is_corresponding":false},{"id":269834,"name":"Chandy C. John","orcid":"0000-0002-1634-1411","position":10,"is_corresponding":false},{"id":445533,"name":"Andrea L. Conroy","orcid":"0000-0002-5328-6511","position":11,"is_corresponding":false},{"id":466930,"name":"Ruth Namazzi","orcid":"0000-0003-2459-6526","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T02:56:05.550545Z","pmid":"39963714","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}