{"doi":"10.1093/infdis/jiae642","title":"Predictive Markers of Incident Tuberculosis in Close Contacts in Brazil and India","abstract":"There are insufficient predictors of progression to tuberculosis among contacts. A case-control study within RePORT-Brazil matched 20 QuantiFERON-positive progressors and 40 nonprogressors by sex, age, and exposure duration. Twentynine cytokines were measured using a Luminex assay with QuantiFERON-TB Gold Plus supernatants collected at baseline and evaluated using machine learning for tuberculosis prediction. The same markers were evaluated in 8 QuantiFERON-positive progressors and 12 nonprogressors from India. Interleukin 8, interleukin 10, and CCL3 levels predicted incident tuberculosis (area under the receiver operating characteristic curve, 0.75) in 2 years with sensitivity and specificity >80%, in both cohorts. This signature predicted tuberculosis progression in close contacts meeting World Health Organization goals.","journal":"The Journal of Infectious Diseases","year":2025,"id":516818,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":386116,"name":"Francys Avendaño-Rangel","orcid":"0000-0001-5315-8168","position":1,"is_corresponding":false},{"id":690322,"name":"Alice M S Andrade","orcid":null,"position":2,"is_corresponding":false},{"id":961491,"name":"Evangeline Ann Daniel","orcid":"0000-0002-7378-717X","position":3,"is_corresponding":false},{"id":689804,"name":"Marina C. Figueiredo","orcid":"0000-0002-0671-398X","position":4,"is_corresponding":false},{"id":1177069,"name":"Cody Staats","orcid":"0009-0002-9044-6382","position":5,"is_corresponding":false},{"id":480077,"name":"Valeria C. Rolla","orcid":null,"position":6,"is_corresponding":false},{"id":110663,"name":"Afranio Kritski","orcid":"0000-0002-5900-6007","position":7,"is_corresponding":false},{"id":689803,"name":"Marcelo Cordeiro‐Santos","orcid":"0000-0002-7140-7145","position":8,"is_corresponding":false},{"id":326405,"name":"Amita Gupta","orcid":"0000-0001-7036-2718","position":9,"is_corresponding":false},{"id":326398,"name":"Luke Elizabeth Hanna","orcid":"0000-0002-6299-8211","position":10,"is_corresponding":false},{"id":240257,"name":"Timothy R. Sterling","orcid":"0000-0002-4822-6979","position":11,"is_corresponding":false},{"id":479093,"name":"Mariana Araújo‐Pereira","orcid":"0000-0002-1141-1580","position":12,"is_corresponding":false},{"id":252301,"name":"Bruno B. Andrade","orcid":"0000-0001-6833-3811","position":13,"is_corresponding":false},{"id":689813,"name":"Betânia M. F. Nogueira","orcid":"0000-0003-4399-4888","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-19T02:48:54.768083Z","pmid":"39763217","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}