{"doi":"10.1093/infdis/jiae394","title":"Vaccine Effectiveness Against Anal HPV Among Men Who Have Sex With Men Aged 18–45 Years Attending Sexual Health Clinics in 3 United States Cities, 2018–2023","abstract":"BACKGROUND: We assessed human papillomavirus (HPV) vaccine effectiveness (VE) against anal HPV among men who have sex with men (MSM) in 2018-2023. METHODS: Residual anal specimens from MSM without HIV aged 18-45 years were tested for HPV. We calculated adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) for associations between vaccination (≥1 dose) and quadrivalent vaccine (4vHPV)-type prevalence adjusting for city, race/ethnicity, and nonvaccine-type HPV prevalence, stratified by age group (18-26, 27-45 years). VE was calculated as (1 - aPR) × 100. RESULTS: Among 2802 persons aged 18-26, 4vHPV-type prevalence was lower in those vaccinated at age <18 (aPR = 0.13; 95% CI, .08-.22; VE = 87%) and those vaccinated ≥2 years before specimen collection (aPR = 0.52; 95% CI, .42-.64; VE = 48%) compared with unvaccinated persons. Among 3548 persons aged 27-45, 4vHPV-type prevalence was lower in those vaccinated at ages 18-26 (aPR = 0.68; 95% CI, .57-.82; VE = 32%) and those vaccinated ≥2 years before specimen collection (aPR = 0.66; 95% CI, .57-.77; VE = 33%) compared with unvaccinated persons. While we observed no VE in persons vaccinated at age >26 overall, 4vHPV-type prevalence was lower in the subgroup vaccinated ≥2 years before specimen collection (aPR = 0.71; 95% CI, .56-.89; VE = 29%). CONCLUSIONS: We found high VE against anal 4vHPV-type prevalence among MSM aged 18-26 who were vaccinated at age <18. Lower VE was observed among MSM aged 27-45 who were vaccinated at age 18-26 or ≥2 years before specimen collection. While ideally vaccination should be given at younger ages, vaccination can prevent some future infections in this population.","journal":"The Journal of Infectious Diseases","year":2024,"id":440943,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355567,"name":"Rachel L. Winer","orcid":"0000-0002-8119-5107","position":1,"is_corresponding":false},{"id":355570,"name":"Troy D. Querec","orcid":"0000-0002-3787-6271","position":2,"is_corresponding":false},{"id":1253386,"name":"Damilola Dada","orcid":null,"position":3,"is_corresponding":false},{"id":461858,"name":"Preeti Pathela","orcid":"0000-0001-9745-6079","position":4,"is_corresponding":false},{"id":327414,"name":"Lenore Asbel","orcid":null,"position":5,"is_corresponding":false},{"id":355572,"name":"John Lin","orcid":"0000-0002-5602-7881","position":6,"is_corresponding":false},{"id":791155,"name":"Jennifer Tang","orcid":"0000-0002-4160-1713","position":7,"is_corresponding":false},{"id":1044715,"name":"Alfred Iqbal","orcid":null,"position":8,"is_corresponding":false},{"id":355566,"name":"Elissa Meites","orcid":"0000-0002-0077-2591","position":9,"is_corresponding":false},{"id":355575,"name":"Elizabeth R. Unger","orcid":"0000-0002-2925-5635","position":10,"is_corresponding":false},{"id":355576,"name":"Lauri E. Markowitz","orcid":"0000-0002-2480-9520","position":11,"is_corresponding":false},{"id":720594,"name":"Carla L. DeSisto","orcid":"0000-0001-9065-7070","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:01:01.842286Z","pmid":"39122662","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}