{"doi":"10.1093/infdis/jiae368","title":"Charting the Impact of Maternal Antibodies and Repeat Exposures on Sapovirus Immunity in Early Childhood From a Nicaraguan Birth Cohort","abstract":"BACKGROUND: Sapovirus is an important cause of acute gastroenteritis in childhood. While vaccines against sapovirus may reduce gastroenteritis burden, a major challenge to their development is a lack of information about natural immunity. METHODS: We measured sapovirus-specific IgG in serum collected between 2017 and 2020 of mothers soon after delivery and at 6 time points in Nicaraguan children until 3 years of age (n = 112 dyads), using virus-like particles representing 3 sapovirus genotypes (GI.1, GI.2, GV.1). RESULTS: Of the 112 children, 16 (14.3%) experienced at least 1 sapovirus gastroenteritis episode, of which GI.1 was the most common genotype. Seroconversion to GI.1 and GI.2 was most common between 5 and 12 months of age, while seroconversion to GV.1 peaked at 18 to 24 months of age. All children who experienced sapovirus GI.1 gastroenteritis seroconverted and developed genotype-specific IgG. The impact of sapovirus exposure on population immunity was determined by antigenic cartography: newborns share their mothers' broadly binding IgG responses, which declined at 5 months of age and then increased as infants experienced natural sapovirus infections. CONCLUSIONS: By tracking humoral immunity to sapovirus over the first 3 years of life, this study provides important insights for the design and timing of future pediatric sapovirus vaccines.","journal":"The Journal of Infectious Diseases","year":2024,"id":468657,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7443,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376982,"name":"Michael L. Mallory","orcid":"0000-0003-0768-572X","position":1,"is_corresponding":false},{"id":811194,"name":"Fredman González","orcid":"0000-0003-2858-8152","position":2,"is_corresponding":false},{"id":495846,"name":"Yaoska Reyes","orcid":"0000-0001-9467-2438","position":3,"is_corresponding":false},{"id":369798,"name":"Nadja A. Vielot","orcid":"0000-0002-9004-0609","position":4,"is_corresponding":false},{"id":105503,"name":"Boyd L. Yount","orcid":"0000-0002-6099-8429","position":5,"is_corresponding":false},{"id":254643,"name":"Amy Sims","orcid":"0000-0003-0178-4225","position":6,"is_corresponding":false},{"id":1220494,"name":"Cameron Nguyen","orcid":"0000-0003-2374-438X","position":7,"is_corresponding":false},{"id":218083,"name":"Kaitlyn Cross","orcid":"0000-0002-6455-9220","position":8,"is_corresponding":false},{"id":811195,"name":"Christian Toval-Ruíz","orcid":"0000-0002-1938-8012","position":9,"is_corresponding":false},{"id":947340,"name":"Lester Gutiérrez","orcid":"0000-0002-5819-3058","position":10,"is_corresponding":false},{"id":291907,"name":"Jan Vinjé","orcid":"0000-0002-1530-3675","position":11,"is_corresponding":false},{"id":5952,"name":"Ralph S. Baric","orcid":"0000-0001-6827-8701","position":12,"is_corresponding":false},{"id":298000,"name":"Lisa C. Lindesmith","orcid":"0000-0001-9567-0522","position":13,"is_corresponding":false},{"id":426091,"name":"Sylvia Becker‐Dreps","orcid":"0000-0002-7808-2507","position":14,"is_corresponding":false},{"id":426092,"name":"Filemón Bucardo","orcid":"0000-0002-9819-870X","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T02:05:23.500722Z","pmid":"39042731","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}