{"doi":"10.1093/infdis/jiae321","title":"Severe West Nile Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Infections in a Patient With Thymoma and Anti–Type I Interferon Antibodies","abstract":"Patients with severe West Nile virus and SARS-CoV-2 infections deserve accurate diagnosis of underlying diseases, determining possible anti-interferon autoantibody production, since they must receive antiviral and immunological therapies to enhance antiviral response. The current study aimed to investigate determinants of severity in a previously healthy patient who experienced 2 life-threatening infections, from West Nile Virus (WNV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). During coronavirus disease 2019 (COVID-19) hospitalization he was diagnosed with a thymoma, retrospectively identified as already present at the time of WNV infection. Heterozygosity for p.Pro554Ser in the TLR3 gene, which increases susceptibility to severe COVID-19, and homozygosity for CCR5 c.554_585del, associated with severe WNV infection, were found. Neutralizing anti-interferon (IFN)-α and anti-IFN-ω autoantibodies were detected, likely induced by the underlying thymoma and increasing susceptibility to both severe COVID-19 pneumonia and West Nile encephalitis.","journal":"The Journal of Infectious Diseases","year":2024,"id":440715,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9608,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1253168,"name":"Camilla Visconti","orcid":null,"position":1,"is_corresponding":false},{"id":1252674,"name":"Giovanni Battista Pipitone","orcid":"0000-0003-2265-3646","position":2,"is_corresponding":false},{"id":617482,"name":"Simone Bondesan","orcid":"0000-0003-4367-8623","position":3,"is_corresponding":false},{"id":1253169,"name":"Giulia Molli","orcid":null,"position":4,"is_corresponding":false},{"id":1253170,"name":"Stefania Giannelli","orcid":null,"position":5,"is_corresponding":false},{"id":1253171,"name":"Claudia Sartirana","orcid":null,"position":6,"is_corresponding":false},{"id":104172,"name":"Vito Lampasona","orcid":"0000-0001-5162-8445","position":7,"is_corresponding":false},{"id":617871,"name":"Elena Bazzigaluppi","orcid":"0000-0002-6715-7454","position":8,"is_corresponding":false},{"id":617868,"name":"Cristina Brigatti","orcid":"0000-0002-2914-1654","position":9,"is_corresponding":false},{"id":615375,"name":"Adrian Gervais","orcid":"0000-0002-1083-5787","position":10,"is_corresponding":false},{"id":104138,"name":"Paul Bastard","orcid":"0000-0002-5926-8437","position":11,"is_corresponding":false},{"id":1252675,"name":"Chiara Tassan Din","orcid":"0000-0002-5362-6897","position":12,"is_corresponding":false},{"id":1252676,"name":"Chiara Molinari","orcid":"0000-0003-1011-5656","position":13,"is_corresponding":false},{"id":104173,"name":"Lorenzo Piemonti","orcid":"0000-0002-2172-2198","position":14,"is_corresponding":false},{"id":57373,"name":"Jean-Laurent Casanova","orcid":"0000-0002-7782-4169","position":15,"is_corresponding":false},{"id":1252677,"name":"Paola Carrera","orcid":"0000-0001-7376-2119","position":16,"is_corresponding":false},{"id":104171,"name":"Giorgio Casari","orcid":"0000-0002-0115-8980","position":17,"is_corresponding":false},{"id":104170,"name":"Alessandro Aiuti","orcid":"0000-0002-5398-1717","position":18,"is_corresponding":false},{"id":274200,"name":"Federica Barzaghi","orcid":"0000-0003-4498-1712","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:01:01.842286Z","pmid":"38976510","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}