{"doi":"10.1093/infdis/jiae315","title":"Plasma From Older Children in Malawi Inhibits <i>Plasmodium falciparum</i> Binding in 3-Dimensional Brain Microvessels","abstract":"A hallmark of cerebral malaria is sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the brain microcirculation. Antibodies contribute to malaria immunity, but it remains unclear whether functional antibodies targeting parasite-expressed ligand can block cytoadhesion in the brain. Here, we screened the plasma of older children and young adults in Malawi to characterize the antibody response against the P. falciparum-IE surface and used a bioengineered 3-dimensional (3D) human brain microvessel model incorporating variable flow dynamics to measure adhesion-blocking responses. We found a strong correlation between surface antibody reactivity by flow cytometry and reduced P. falciparum-IE binding in 3D microvessels. Moreover, there was a threshold of surface antibody reactivity necessary to achieve robust inhibitory activity. Our findings provide evidence of the acquisition of adhesion-blocking antibodies against cerebral binding variants in people exposed to stable P. falciparum transmission and suggest the quality of the inhibitory response can be influenced by flow dynamics.","journal":"The Journal of Infectious Diseases","year":2024,"id":442636,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9598,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":820823,"name":"Ruoqian Hu","orcid":"0009-0002-6103-4063","position":1,"is_corresponding":false},{"id":1236202,"name":"Alex Saidi","orcid":"0000-0002-8949-673X","position":2,"is_corresponding":false},{"id":75973,"name":"Karl B. Seydel","orcid":"0000-0001-9859-9549","position":3,"is_corresponding":false},{"id":260116,"name":"Lauren M. Cohee","orcid":"0000-0002-7575-630X","position":4,"is_corresponding":false},{"id":281119,"name":"Ying Zheng","orcid":"0000-0003-2723-9022","position":5,"is_corresponding":false},{"id":281118,"name":"Joseph D. Smith","orcid":"0000-0002-7915-6360","position":6,"is_corresponding":false},{"id":1063750,"name":"Fatou Joof","orcid":"0009-0002-9731-9239","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:01:20.107161Z","pmid":"38875153","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}