{"doi":"10.1093/infdis/jiae237","title":"Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil","abstract":"BACKGROUND: Approximately 5% of people infected with Mycobacterium tuberculosis progress to tuberculosis (TB) disease without preventive therapy. There is a need for a prognostic test to identify those at highest risk of incident TB so that therapy can be targeted. We evaluated host blood transcriptomic signatures for progression to TB disease. METHODS: Close contacts (≥4 hours of exposure per week) of adult patients with culture-confirmed pulmonary TB were enrolled in Brazil. Investigation for incident, microbiologically confirmed, or clinically diagnosed pulmonary or extrapulmonary TB disease through 24 months of follow-up was symptom triggered. Twenty previously validated blood TB transcriptomic signatures were measured at baseline by real-time quantitative polymerase chain reaction. Prognostic performance for incident TB was tested by receiver operating characteristic curve analysis at 6, 9, 12, and 24 months of follow-up. RESULTS: Between June 2015 and June 2019, 1854 close contacts were enrolled. Twenty-five progressed to incident TB, of whom 13 had microbiologically confirmed disease. Baseline transcriptomic signature scores were measured in 1789 close contacts. Prognostic performance for all signatures was best within 6 months of diagnosis. Seven signatures (Gliddon4, Suliman4, Roe3, Roe1, Penn-Nicholson6, Francisco2, and Rajan5) met the minimum World Health Organization target product profile for a prognostic test through 6 months and 3 signatures (Gliddon4, Rajan5, and Duffy9) through 9 months. None met the target product profile threshold through ≥12 months of follow-up. CONCLUSIONS: Blood transcriptomic signatures may be useful for predicting TB risk within 9 months of measurement among TB-exposed contacts to target preventive therapy administration.","journal":"The Journal of Infectious Diseases","year":2024,"id":426432,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8706,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":252301,"name":"Bruno B. Andrade","orcid":"0000-0001-6833-3811","position":1,"is_corresponding":false},{"id":252289,"name":"Stanley Kimbung Mbandi","orcid":"0000-0001-6121-9039","position":2,"is_corresponding":false},{"id":690322,"name":"Alice M S Andrade","orcid":null,"position":3,"is_corresponding":false},{"id":1225338,"name":"Vanessa Mwebaza Muwanga","orcid":"0000-0002-9415-5438","position":4,"is_corresponding":false},{"id":689804,"name":"Marina C. Figueiredo","orcid":"0000-0002-0671-398X","position":5,"is_corresponding":false},{"id":253348,"name":"Mzwandile Erasmus","orcid":null,"position":6,"is_corresponding":false},{"id":689805,"name":"Valéria C. Rolla","orcid":"0000-0002-0841-1408","position":7,"is_corresponding":false},{"id":1225339,"name":"Prisca K. Thami","orcid":"0000-0002-4550-2560","position":8,"is_corresponding":false},{"id":689803,"name":"Marcelo Cordeiro‐Santos","orcid":"0000-0002-7140-7145","position":9,"is_corresponding":false},{"id":252288,"name":"Adam Penn‐Nicholson","orcid":"0000-0002-1883-0059","position":10,"is_corresponding":false},{"id":110663,"name":"Afranio Kritski","orcid":"0000-0002-5900-6007","position":11,"is_corresponding":false},{"id":231909,"name":"Mark Hatherill","orcid":"0000-0003-3491-1809","position":12,"is_corresponding":false},{"id":240257,"name":"Timothy R. Sterling","orcid":"0000-0002-4822-6979","position":13,"is_corresponding":false},{"id":252307,"name":"Thomas J. Scriba","orcid":"0000-0002-0641-1359","position":14,"is_corresponding":false},{"id":1225832,"name":"the RePORT–South Africa and RePORT–Brazil Consortia","orcid":null,"position":15,"is_corresponding":false},{"id":253349,"name":"Nicole Bilek","orcid":null,"position":16,"is_corresponding":false},{"id":253358,"name":"Yolundi Cloete","orcid":null,"position":17,"is_corresponding":false},{"id":252295,"name":"Michelle Fisher","orcid":"0000-0003-1414-7612","position":19,"is_corresponding":false},{"id":679187,"name":"Katie Hadley","orcid":null,"position":20,"is_corresponding":false},{"id":679238,"name":"Rieyaat Hassiem","orcid":null,"position":21,"is_corresponding":false},{"id":679188,"name":"Lungisa Jaxa","orcid":null,"position":23,"is_corresponding":false},{"id":1225833,"name":"Faheemah Meyer","orcid":null,"position":26,"is_corresponding":false},{"id":1225834,"name":"Vanessa M Muwanga","orcid":null,"position":27,"is_corresponding":false},{"id":679190,"name":"Onke Nombida","orcid":null,"position":28,"is_corresponding":false},{"id":691408,"name":"Adam Penn-Nicholson","orcid":null,"position":29,"is_corresponding":false},{"id":679189,"name":"Rodney Raphela","orcid":null,"position":30,"is_corresponding":false},{"id":1225340,"name":"Alison V. September","orcid":"0000-0003-0950-286X","position":32,"is_corresponding":false},{"id":253357,"name":"Ashley Veldsman","orcid":null,"position":35,"is_corresponding":false},{"id":1225835,"name":"Alice Oliveira Andrade","orcid":null,"position":36,"is_corresponding":false},{"id":1225836,"name":"Bruno B Andrade","orcid":null,"position":37,"is_corresponding":false},{"id":1225837,"name":"Brenda Carvalho","orcid":null,"position":38,"is_corresponding":false},{"id":1225838,"name":"Adriano Gomes","orcid":null,"position":41,"is_corresponding":false},{"id":1225839,"name":"Afranio L Kritski","orcid":null,"position":42,"is_corresponding":false},{"id":1225840,"name":"Valeria C Rolla","orcid":null,"position":43,"is_corresponding":false},{"id":252290,"name":"Simon C. Mendelsohn","orcid":"0000-0002-4054-2766","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:58:37.924718Z","pmid":"38709708","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}