{"doi":"10.1093/infdis/jiae225","title":"Genomic Diversity and Antimicrobial Susceptibility of Invasive <i>Neisseria meningitidis</i> in South Africa, 2016–2021","abstract":"BACKGROUND: Invasive meningococcal isolates in South Africa have in previous years (<2008) been characterized by serogroup B, C, W, and Y lineages over time, with penicillin intermediate resistance (peni) at 6%. We describe the population structure and genomic markers of peni among invasive meningococcal isolates in South Africa, 2016-2021. METHODS: Meningococcal isolates were collected through national, laboratory-based invasive meningococcal disease (IMD) surveillance. Phenotypic antimicrobial susceptibility testing and whole-genome sequencing were performed, and the mechanism of reduced penicillin susceptibility was assessed in silico. RESULTS: Of 585 IMD cases reported during the study period, culture and PCR-based capsular group was determined for 477/585 (82%); and 241/477 (51%) were sequenced. Predominant serogroups included NmB (210/477; 44%), NmW (116/477; 24%), NmY (96/477; 20%), and NmC (48/477; 10%). Predominant clonal complexes (CC) were CC41/44 in NmB (27/113; 24%), CC11 in NmW (46/56; 82%), CC167 in NmY (23/44; 53%), and CC865 in NmC (9/24; 38%). Peni was detected in 16% (42/262) of isolates, and was due to the presence of a penA mosaic, with the majority harboring penA7, penA9, or penA14. CONCLUSIONS: IMD lineages circulating in South Africa were consistent with those circulating prior to 2008; however, peni was higher than previously reported, and occurred in a variety of lineages.","journal":"The Journal of Infectious Diseases","year":2024,"id":476718,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5819,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":138619,"name":"Susan Meiring","orcid":"0000-0003-4508-5469","position":1,"is_corresponding":false},{"id":680424,"name":"Linda de Gouveia","orcid":"0000-0002-1418-8468","position":2,"is_corresponding":false},{"id":1314227,"name":"Wai Chan","orcid":"0000-0002-7344-2606","position":3,"is_corresponding":false},{"id":294744,"name":"Keith A. Jolley","orcid":"0000-0002-0751-0287","position":4,"is_corresponding":false},{"id":302051,"name":"Daria Van Tyne","orcid":"0000-0001-7284-0103","position":5,"is_corresponding":false},{"id":281657,"name":"Lee H. Harrison","orcid":"0000-0002-3787-2705","position":6,"is_corresponding":false},{"id":794005,"name":"Henju Marjuki","orcid":"0000-0002-9153-5929","position":7,"is_corresponding":false},{"id":239824,"name":"Arshad Ismail","orcid":"0000-0003-4672-5915","position":8,"is_corresponding":false},{"id":856479,"name":"Vanessa Quan","orcid":"0000-0003-1666-4752","position":9,"is_corresponding":false},{"id":227049,"name":"Cheryl Cohen","orcid":"0000-0003-0376-2302","position":10,"is_corresponding":false},{"id":227093,"name":"Sibongile Walaza","orcid":"0000-0001-7588-2480","position":11,"is_corresponding":false},{"id":227091,"name":"Anne von Gottberg","orcid":"0000-0002-0243-7455","position":12,"is_corresponding":false},{"id":680425,"name":"Mignon du Plessis","orcid":"0000-0001-9186-0679","position":13,"is_corresponding":false},{"id":1314226,"name":"Rito L Mikhari","orcid":"0000-0002-6608-9162","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T02:06:29.605760Z","pmid":"38687883","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}