{"doi":"10.1093/infdis/jiae141","title":"Effect of Leptin Receptor Q223R Polymorphism on <i>Clostridioides difficile</i> Infection–Induced Macrophage Migration Inhibitory Factor Production","abstract":"Proinflammatory cytokine levels and host genetic makeup are key determinants of Clostridioides difficile infection (CDI) outcomes. We previously reported that blocking the inflammatory cytokine macrophage migration inhibitory factor (MIF) ameliorates CDI. Here, we determined kinetics of MIF production and its association with a common genetic variant in leptin receptor (LEPR) using blood from patients with CDI. We found highest plasma MIF early after C difficile exposure and in individuals who express mutant/derived LEPR. Our data suggest that early-phase CDI provides a possible window of opportunity in which MIF targeting, potentially in combination with LEPR genotype, could have therapeutic utility.","journal":"The Journal of Infectious Diseases","year":2024,"id":473319,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":740163,"name":"A. Huber","orcid":"0000-0003-2633-962X","position":1,"is_corresponding":false},{"id":1309387,"name":"Rowis Sous","orcid":null,"position":2,"is_corresponding":false},{"id":1173069,"name":"Kristin N. Weghorn","orcid":null,"position":3,"is_corresponding":false},{"id":1064576,"name":"Margaret V. Powers‐Fletcher","orcid":"0000-0002-3825-1150","position":4,"is_corresponding":false},{"id":740162,"name":"Shinsmon Jose","orcid":"0000-0002-0552-7421","position":5,"is_corresponding":false},{"id":706419,"name":"Rajat Madan","orcid":"0000-0002-9821-1257","position":6,"is_corresponding":false},{"id":1172722,"name":"Ann Mathew","orcid":"0009-0006-0540-7477","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T02:06:01.000126Z","pmid":"38687212","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}