{"doi":"10.1093/infdis/jiae060","title":"Nuclear Factor κB Signaling Deficiency in CD11c-Expressing Phagocytes Mediates Early Inflammatory Responses and Enhances <i>Mycobacterium tuberculosis</i> Control","abstract":"Early innate immune responses play an important role in determining the protective outcome of Mycobacterium tuberculosis (Mtb) infection. Nuclear factor κB (NF-κB) signaling in immune cells regulates the expression of key downstream effector molecules that mount early antimycobacterial responses. Using conditional knockout mice, we studied the effect of abrogation of NF-κB signaling in different myeloid cell types and its impact on Mtb infection. Our results show that the absence of IKK2-mediated signaling in all myeloid cells resulted in increased susceptibility to Mtb infection. In contrast, the absence of IKK2-mediated signaling in CD11c+ myeloid cells induced early proinflammatory cytokine responses, enhanced the recruitment of myeloid cells, and mediated early resistance to Mtb. Abrogation of IKK2 in MRP8-expressing neutrophils did not affect disease pathology or Mtb control. Thus, we describe an early immunoregulatory role for NF-κB signaling in CD11c-expressing phagocytes and a later protective role for NF-κB in LysM-expressing cells during Mtb infection.","journal":"The Journal of Infectious Diseases","year":2024,"id":457166,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":366587,"name":"Micah Dunlap","orcid":"0000-0002-6585-9655","position":1,"is_corresponding":false},{"id":857738,"name":"Sadia Akter","orcid":"0000-0002-7296-7304","position":2,"is_corresponding":false},{"id":246483,"name":"Ananya Gupta","orcid":"0000-0001-7917-7877","position":3,"is_corresponding":false},{"id":245277,"name":"Mushtaq Ahmed","orcid":"0000-0002-6296-7626","position":4,"is_corresponding":false},{"id":245278,"name":"Bruce A. Rosa","orcid":"0000-0002-6820-446X","position":5,"is_corresponding":false},{"id":1282860,"name":"Noreen B Dela Peña","orcid":null,"position":6,"is_corresponding":false},{"id":29027,"name":"Makedonka Mitreva","orcid":"0000-0001-9572-3436","position":7,"is_corresponding":false},{"id":225184,"name":"Shabaana A. Khader","orcid":"0000-0002-9545-4982","position":8,"is_corresponding":false},{"id":857739,"name":"Kuldeep S Chauhan","orcid":"0009-0009-4038-1411","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:03:37.136946Z","pmid":"38324907","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}