{"doi":"10.1093/infdis/jiae054","title":"New Window Into Hepatitis B in Africa: Liver Sampling Combined With Single-Cell Omics Enables Deep and Longitudinal Assessment of Intrahepatic Immunity in Zambia","abstract":"In Lusaka, Zambia, we introduced liver fine-needle aspiration biopsy (FNAB) into a research cohort of adults with treatment-naive chronic hepatitis B virus (HBV) infection, with and without human immunodeficiency virus (HIV) coinfection, as well as with acute HBV infection. From 117 enrollment and 47 longitudinal FNABs (at 1-year follow-up), we established participant acceptability and safety. We also demonstrated the quality of the material through single-cell RNA sequencing of selected enrollment FNAs, which revealed a range of immune cells. This approach can drive new insights into HBV immunology, informing cure strategies, and can improve our understanding of HBV natural history in Africa.","journal":"The Journal of Infectious Diseases","year":2024,"id":470490,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.843,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1033092,"name":"Michael S. Wallace","orcid":"0000-0002-9679-6546","position":1,"is_corresponding":false},{"id":1033831,"name":"Hailey Patel","orcid":null,"position":2,"is_corresponding":false},{"id":1305280,"name":"Owen P. Martin","orcid":null,"position":3,"is_corresponding":false},{"id":1031002,"name":"Christopher Oetheimer","orcid":"0000-0001-7905-1211","position":4,"is_corresponding":false},{"id":493733,"name":"Simutanyi Mwakamui","orcid":"0000-0001-7667-6531","position":5,"is_corresponding":false},{"id":329540,"name":"Edford Sinkala","orcid":"0000-0002-5756-5569","position":6,"is_corresponding":false},{"id":393584,"name":"Bright Nsokolo","orcid":"0000-0002-9338-0350","position":7,"is_corresponding":false},{"id":394385,"name":"Annie Kanunga","orcid":null,"position":8,"is_corresponding":false},{"id":331565,"name":"Georg M. Lauer","orcid":"0000-0002-9792-4271","position":9,"is_corresponding":false},{"id":270866,"name":"Raymond T. Chung","orcid":"0000-0001-7587-718X","position":10,"is_corresponding":false},{"id":364593,"name":"Gilles Wandeler","orcid":"0000-0002-5278-8763","position":11,"is_corresponding":false},{"id":442329,"name":"Debika Bhattacharya","orcid":"0000-0002-2136-7763","position":12,"is_corresponding":false},{"id":292863,"name":"Paul Kelly","orcid":"0000-0003-0844-6448","position":13,"is_corresponding":false},{"id":612119,"name":"Nadia Alatrakchi","orcid":"0000-0001-7600-564X","position":14,"is_corresponding":false},{"id":393581,"name":"Michael J. Vinikoor","orcid":"0000-0002-3862-7795","position":15,"is_corresponding":false},{"id":1098672,"name":"Taonga Musonda","orcid":"0009-0008-9533-448X","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T02:05:40.740958Z","pmid":"38332750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}