{"doi":"10.1093/infdis/jiad576","title":"IL-32 Drives the Differentiation of Cardiotropic CD4+ T Cells Carrying HIV DNA in People With HIV","abstract":"Interleukin 32 (IL-32) is a potent multi-isoform proinflammatory cytokine, which is upregulated in people with HIV (PWH) and is associated with cardiovascular disease (CVD) risk. However, the impact of IL-32 isoforms on CD4 T-cell cardiotropism, a mechanism potentially contributing to heart inflammation, remains unknown. Here we show that IL-32 isoforms β and γ induce the generation of CCR4+CXCR3+ double positive (DP) memory CD4 T-cell subpopulation expressing the tyrosine kinase receptor c-Met, a phenotype associated with heart-homing of T cells. Our ex vivo studies on PWH show that the frequency of DP CD4 T cells is significantly higher in individuals with, compared to individuals without, subclinical atherosclerosis and that DP cells from antiretroviral-naive and treated individuals are highly enriched with HIV DNA. Together, these data demonstrate that IL-32 isoforms have the potential to induce heart-homing of HIV-infected CD4 T cells, which may further aggravate heart inflammation and CVD in PWH.","journal":"The Journal of Infectious Diseases","year":2023,"id":366573,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":18098,"name":"Annie Gosselin","orcid":null,"position":1,"is_corresponding":false},{"id":660820,"name":"Rémi Bunet","orcid":null,"position":2,"is_corresponding":false},{"id":1123263,"name":"Mohammad-Ali Jenabian","orcid":"0000-0001-8261-2948","position":3,"is_corresponding":false},{"id":660819,"name":"Mohamed Sylla","orcid":null,"position":4,"is_corresponding":false},{"id":399936,"name":"Amélie Pagliuzza","orcid":"0000-0001-8124-2607","position":5,"is_corresponding":false},{"id":659747,"name":"Carl Chartrand‐Lefebvre","orcid":"0000-0002-2299-7855","position":6,"is_corresponding":false},{"id":233493,"name":"Jean‐Pierre Routy","orcid":"0000-0001-9897-7589","position":7,"is_corresponding":false},{"id":487405,"name":"Jean-Philippe Goulet","orcid":null,"position":8,"is_corresponding":false},{"id":659752,"name":"Réjean Thomas","orcid":"0000-0002-9112-3561","position":9,"is_corresponding":false},{"id":659751,"name":"Benoît Trottier","orcid":"0000-0002-9285-848X","position":10,"is_corresponding":false},{"id":623265,"name":"Valérie Martel‐Laferrière","orcid":"0000-0001-7973-8582","position":11,"is_corresponding":false},{"id":1123264,"name":"Claude Fortin","orcid":"0000-0002-2479-1869","position":12,"is_corresponding":false},{"id":235294,"name":"Nicolas Chomont","orcid":"0000-0001-9747-5018","position":13,"is_corresponding":false},{"id":342350,"name":"Rémi Fromentin","orcid":"0000-0002-8153-1799","position":14,"is_corresponding":false},{"id":328573,"name":"Alan Landay","orcid":"0000-0001-9645-1356","position":15,"is_corresponding":false},{"id":619015,"name":"Madéleine Durand","orcid":"0000-0002-9459-9549","position":16,"is_corresponding":false},{"id":18101,"name":"Petronela Ancuța","orcid":"0000-0003-1922-5640","position":17,"is_corresponding":false},{"id":659745,"name":"Mohamed El‐Far","orcid":"0000-0002-6458-4207","position":18,"is_corresponding":false},{"id":17392,"name":"Cécile Tremblay","orcid":"0000-0002-3440-3436","position":19,"is_corresponding":false},{"id":660821,"name":"Hardik B. Ramani","orcid":null,"position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:14:59.372548Z","pmid":"38113908","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}