{"doi":"10.1093/infdis/jiad469","title":"Naturally Acquired Transmission-Blocking Immunity Against Different Strains of <i>Plasmodium vivax</i> in a Malaria-Endemic Area in Thailand","abstract":"BACKGROUND: Human immunity triggered by natural malaria infections impedes parasite transmission from humans to mosquitoes, leading to interest in transmission-blocking vaccines. However, immunity characteristics, especially strain specificity, remain largely unexplored. We investigated naturally acquired transmission-blocking immunity (TBI) against Plasmodium vivax, a major malaria parasite. METHODS: Using the direct membrane-feeding assay, we assessed TBI in plasma samples and examined the role of antibodies by removing immunoglobulins through protein G/L adsorption before mosquito feeding. Strain specificity was evaluated by conducting a direct membrane-feeding assay with plasma exchange. RESULTS: Blood samples from 47 patients with P vivax were evaluated, with 37 plasma samples successfully infecting mosquitoes. Among these, 26 showed inhibition before immunoglobulin depletion. Despite substantial immunoglobulin removal, 4 samples still exhibited notable inhibition, while 22 had reduced blocking activity. Testing against heterologous strains revealed some plasma samples with broad TBI and others with strain-specific TBI. CONCLUSIONS: Our findings indicate that naturally acquired TBI is mainly mediated by antibodies, with possible contributions from other serum factors. The transmission-blocking activity of plasma samples varied by the tested parasite strain, suggesting single polymorphic or multiple targets for naturally acquired TBI. These observations improve understanding of immunity against P vivax and hold implications for transmission-blocking vaccine development.","journal":"The Journal of Infectious Diseases","year":2023,"id":379982,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9648,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334656,"name":"Wanlapa Roobsoong","orcid":"0000-0002-1789-0439","position":1,"is_corresponding":false},{"id":406895,"name":"Wang Nguitragool","orcid":"0000-0002-5484-7130","position":2,"is_corresponding":false},{"id":713206,"name":"Sadudee Chotirat","orcid":"0000-0002-2893-5209","position":3,"is_corresponding":false},{"id":339355,"name":"Takafumi Tsuboi","orcid":"0000-0002-7415-1325","position":4,"is_corresponding":false},{"id":339354,"name":"Eizo Takashima","orcid":"0000-0001-9070-8499","position":5,"is_corresponding":false},{"id":308914,"name":"Liwang Cui","orcid":"0000-0002-8338-1974","position":6,"is_corresponding":false},{"id":875134,"name":"Tomoko Ishino","orcid":"0000-0003-2466-711X","position":7,"is_corresponding":false},{"id":148816,"name":"Mayumi Tachibana","orcid":null,"position":8,"is_corresponding":false},{"id":329084,"name":"Kazutoyo Miura","orcid":"0000-0003-4455-2432","position":9,"is_corresponding":false},{"id":334155,"name":"Jetsumon Sattabongkot","orcid":"0000-0002-3938-4588","position":10,"is_corresponding":false},{"id":335771,"name":"Sataporn Thongpoon","orcid":null,"position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T01:17:00.789848Z","pmid":"37943633","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}