{"doi":"10.1093/infdis/jiad404","title":"Chagas Disease Diagnostic Practices at Four Major Hospital Systems in California and Texas","abstract":"BACKGROUND: Chagas disease (CD) is a parasitic disease that affects ∼300 000 people living in the United States. CD leads to cardiac and/or gastrointestinal disease in up to 30% of untreated people. However, end-organ damage can be prevented with early diagnosis and antiparasitic therapy. METHODS: We reviewed electronic health records of patients who underwent testing for CD at four hospital systems in California and Texas between 2016 and 2020. Descriptive analyses were performed as a needs assessment for improving CD diagnosis. RESULTS: In total, 470 patients were tested for CD. Cardiac indications made up more than half (60%) of all testing, and the most frequently cited cardiac condition was heart failure. Fewer than 1% of tests were ordered by obstetric and gynecologic services. Fewer than half (47%) of patients had confirmatory testing performed at the Centers for Disease Control and Prevention. DISCUSSION: Four major hospitals systems in California and Texas demonstrated low overall rates of CD diagnostic testing, testing primarily among older patients with end-organ damage, and incomplete confirmatory testing. This suggests missed opportunities to diagnose CD in at-risk individuals early in the course of infection when antiparasitic treatment can reduce the risk of disease progression and prevent vertical transmission.","journal":"The Journal of Infectious Diseases","year":2023,"id":379142,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.673,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1144015,"name":"Jose I Echeverri Alegre","orcid":null,"position":1,"is_corresponding":false},{"id":1143580,"name":"Katherine Promer","orcid":"0000-0002-5280-7629","position":2,"is_corresponding":false},{"id":1138626,"name":"Jesica Hayon","orcid":null,"position":3,"is_corresponding":false},{"id":1143581,"name":"Roumen Iordanov","orcid":"0000-0002-7554-4737","position":4,"is_corresponding":false},{"id":1143582,"name":"Khuzaima Rangwalla","orcid":"0000-0001-6703-0421","position":5,"is_corresponding":false},{"id":574436,"name":"Jerry J. Zhang","orcid":"0000-0002-8106-2865","position":6,"is_corresponding":false},{"id":1144016,"name":"Zian Fang","orcid":null,"position":7,"is_corresponding":false},{"id":841715,"name":"Cindy Huang","orcid":"0009-0002-5386-6345","position":8,"is_corresponding":false},{"id":818875,"name":"Cassiana E. Bittencourt","orcid":null,"position":9,"is_corresponding":false},{"id":314431,"name":"Sharon L. Reed","orcid":"0000-0001-7615-9366","position":10,"is_corresponding":false},{"id":574437,"name":"Rosa M. Andrade","orcid":"0000-0002-8802-1118","position":11,"is_corresponding":false},{"id":235422,"name":"Caryn Bern","orcid":"0000-0001-8195-7303","position":12,"is_corresponding":false},{"id":89638,"name":"Eva H. Clark","orcid":"0000-0002-0350-8753","position":13,"is_corresponding":false},{"id":235384,"name":"Jeffrey D. Whitman","orcid":"0000-0002-3502-5799","position":14,"is_corresponding":false},{"id":1085811,"name":"Emily Kelly","orcid":"0000-0003-2986-0285","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:16:52.622552Z","pmid":"37853514","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}