{"doi":"10.1093/infdis/jiad310","title":"Effects of Maternal HIV Infection on Early Kaposi Sarcoma-Associated Herpesvirus Seroconversion in a Kenyan Mother-Infant Cohort","abstract":"BACKGROUND: We identified whether maternal human immunodeficiency virus (HIV) infection during pregnancy affects transplacental transfer of Kaposi sarcoma-associated herpesvirus (KSHV)-specific antibodies and subsequent infant infection. METHODS: We followed pregnant Kenyan women through delivery and their infants until age 2 years. Children were classified as HIV-exposed uninfected (HEU) or HIV-unexposed uninfected (HUU) based on maternal HIV status. Maternal venous and cord blood at delivery and child venous blood every 6 months were tested for antibodies to 20 KSHV antigens by multiplex bead-based immunoassay. Multiple comparisons were adjusted using false discovery rate (FDR). RESULTS: Maternal HIV infection was significantly associated with decreased transplacental transfer of antibodies against all KSHV antigens and lower cord blood levels for 8 antigens at FDR P < .10. Neither birth to 6-month antibody level changes nor 6-month levels differed in HEU and HUU, except for ORF50. By age 24 months, 74% of children KSHV seroconverted but HEU and HUU did not differ in time to seroconversion nor 2-year seropositivity after adjustment for child malaria infection. CONCLUSIONS: Maternal HIV infection reduced a child's initial KSHV antibody levels but did not affect age of infection. Regardless of HIV exposure in utero, KSHV seroconversion in Kenyan children occurred early; associated factors must be identified.","journal":"The Journal of Infectious Diseases","year":2023,"id":379754,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.928,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":504574,"name":"Sidney Ogolla","orcid":"0000-0003-1570-6164","position":1,"is_corresponding":false},{"id":1144863,"name":"Gabriela Samayoa Reyes","orcid":null,"position":2,"is_corresponding":false},{"id":504573,"name":"Ibrahim Daud","orcid":"0000-0002-5492-8782","position":3,"is_corresponding":false},{"id":523719,"name":"Conner Jackson","orcid":"0000-0002-3519-5667","position":4,"is_corresponding":false},{"id":595081,"name":"Nazzarena Labo","orcid":null,"position":5,"is_corresponding":false},{"id":432332,"name":"Wendell Miley","orcid":"0000-0001-8435-9982","position":6,"is_corresponding":false},{"id":351604,"name":"Denise Whitby","orcid":"0000-0002-7407-2563","position":7,"is_corresponding":false},{"id":441634,"name":"Molly M. Lamb","orcid":"0000-0002-2331-2555","position":8,"is_corresponding":false},{"id":504575,"name":"Rosemary Rochford","orcid":"0000-0002-0001-5152","position":9,"is_corresponding":false},{"id":548432,"name":"Arlene E. Dent","orcid":"0000-0003-2265-7938","position":10,"is_corresponding":false},{"id":504572,"name":"Katherine R. Sabourin","orcid":"0000-0002-6147-9196","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:16:56.650289Z","pmid":"37536370","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}