{"doi":"10.1093/infdis/jiad276","title":"Safety and Immunogenicity of a Delayed Heterologous Avian Influenza A(H7N9) Vaccine Boost Following Different Priming Regimens: A Randomized Clinical Trial","abstract":"BACKGROUND: Influenza A (H7N9) has caused multiple disease waves with evidence of strain diversification. Optimal influenza A (H7N9) prime-boost vaccine strategies are unknown. METHODS: We recruited participants who had received monovalent inactivated A/Shanghai/2/2013 (H7N9) vaccine (MIV) approximately 5 years earlier, as follows: MIV with MF59 (MF59 × 2 group), MIV with AS03 (AS03 × 2 group), unadjuvanted MIV (No Adj group), MIV with MF59 or AS03 followed by unadjuvanted MIV (Adjx1 group), and A/H7-naive (unprimed group). Participants were randomized to receive 1 dose of AS03-adjuvanted or unadjuvanted A/Hong Kong/125/2017 (H7N9) MIV and were followed for safety and immunogenicity using hemagglutination inhibition (HAI) and neutralizing antibody assays. RESULTS: We enrolled 304 participants: 153 received the adjuvanted boost and 151 received the unadjuvanted boost. At 21 days postvaccination, the proportion of participants with HAI antibody titers against the boosting vaccine strain of ≥40 in the adjuvanted and unadjuvanted arms, respectively, were 88% and 49% in MF59 × 2 group, 89% and 75% in AS03 × 2 group, 59% and 20% in No Adj group, 94% and 55% in Adjx1group, and 9% and 11% in unprimed group. CONCLUSIONS: Serologic responses to a heterologous A(H7N9) MIV boost were highest in participants primed and boosted with adjuvant-containing regimens. CLINICAL TRIALS REGISTRATION: NCT03738241.","journal":"The Journal of Infectious Diseases","year":2023,"id":354019,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8908,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03738241"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":409698,"name":"İnci Yıldırım","orcid":"0000-0002-8631-0020","position":1,"is_corresponding":false},{"id":332257,"name":"Sharon E. Frey","orcid":"0009-0008-6313-4053","position":2,"is_corresponding":false},{"id":332255,"name":"Patricia Winokur","orcid":"0000-0002-4826-1790","position":3,"is_corresponding":false},{"id":218071,"name":"Lisa A. Jackson","orcid":"0000-0002-1785-0218","position":4,"is_corresponding":false},{"id":381556,"name":"David I. Bernstein","orcid":"0000-0002-0100-1991","position":5,"is_corresponding":false},{"id":103450,"name":"C. Buddy Creech","orcid":"0000-0002-8276-9053","position":6,"is_corresponding":false},{"id":415859,"name":"Wilbur H. Chen","orcid":"0000-0001-7741-5536","position":7,"is_corresponding":false},{"id":803915,"name":"Richard Rupp","orcid":"0000-0002-9659-1217","position":8,"is_corresponding":false},{"id":844021,"name":"Jennifer A. Whitaker","orcid":"0000-0002-7727-6086","position":9,"is_corresponding":false},{"id":218089,"name":"Varun K. Phadke","orcid":"0000-0002-0318-4939","position":10,"is_corresponding":false},{"id":251513,"name":"Daniel F. Hoft","orcid":"0000-0002-8921-4093","position":11,"is_corresponding":false},{"id":651866,"name":"Dilek İnce","orcid":"0000-0001-5446-3789","position":12,"is_corresponding":false},{"id":803916,"name":"Rebecca C. Brady","orcid":"0000-0002-7635-6172","position":13,"is_corresponding":false},{"id":294609,"name":"Kathryn M. Edwards","orcid":"0000-0003-3912-9832","position":14,"is_corresponding":false},{"id":61306,"name":"Justin R. Ortiz","orcid":"0000-0002-3138-5965","position":15,"is_corresponding":false},{"id":1101099,"name":"Megan A Berman","orcid":null,"position":16,"is_corresponding":false},{"id":70581,"name":"Julia Weiß","orcid":"0000-0003-2432-2613","position":17,"is_corresponding":false},{"id":760580,"name":"Ashley Wegel","orcid":"0000-0002-1643-0668","position":18,"is_corresponding":false},{"id":1101100,"name":"DMID 17-0090 Study Group","orcid":null,"position":19,"is_corresponding":false},{"id":29108,"name":"Wendy A. Keitel","orcid":null,"position":20,"is_corresponding":false},{"id":103449,"name":"Robert L. Atmar","orcid":"0000-0001-9989-6772","position":21,"is_corresponding":false},{"id":94488,"name":"Christina A. Rostad","orcid":"0000-0001-8439-0592","position":22,"is_corresponding":false},{"id":104987,"name":"Nadine Rouphael","orcid":"0000-0002-2512-7919","position":23,"is_corresponding":false},{"id":94484,"name":"Evan J. Anderson","orcid":"0000-0002-1576-4420","position":24,"is_corresponding":false},{"id":38190,"name":"Robert W. Frenck","orcid":"0000-0002-2336-526X","position":25,"is_corresponding":false},{"id":655967,"name":"Michelle Dickey","orcid":null,"position":26,"is_corresponding":false},{"id":242121,"name":"Karen L. Kotloff","orcid":"0000-0003-1808-6431","position":27,"is_corresponding":false},{"id":38212,"name":"Kathleen M. Neuzil","orcid":"0000-0001-9480-2714","position":28,"is_corresponding":false},{"id":1028932,"name":"Irene Graham","orcid":null,"position":29,"is_corresponding":false},{"id":332248,"name":"Getahun Abate","orcid":"0000-0002-7825-2422","position":30,"is_corresponding":false},{"id":98392,"name":"Hana M. El Sahly","orcid":"0000-0003-0489-0074","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:13:02.680107Z","pmid":"37466221","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}