{"doi":"10.1093/infdis/jiad211","title":"Use of Next-Generation Sequencing in a State-Wide Strategy of HIV-1 Surveillance: Impact of the SARS-COV-2 Pandemic on HIV-1 Diagnosis and Transmission","abstract":"BACKGROUND: The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic posed an unpreceded threat to the management of other pandemics such as human immunodeficiency virus-1 (HIV-1) in the United States. The full impact of the SARS-CoV-2 pandemic on the HIV-1 pandemic needs to be evaluated. METHODS: All individuals with newly reported HIV-1 diagnoses from NC State Laboratory of Public Health were enrolled in this prospective observational study, 2018-2021. We used a sequencing-based recency assay to identify recent HIV-1 infections and to determine the days postinfection (DPI) for each person at the time of diagnosis. RESULTS: Sequencing used diagnostic serum samples from 814 individuals with new HIV-1 diagnoses spanning this 4-year period. Characteristics of individuals diagnosed in 2020 differed from those in other years. People of color diagnosed in 2021 were on average 6 months delayed in their diagnosis compared to those diagnosed in 2020. There was a trend that genetic networks were more known for individuals diagnosed in 2021. We observed no major integrase resistance mutations over the course of the study. CONCLUSIONS: SARS-CoV-2 pandemic may contribute to the spread of HIV-1. Public health resources need to focus on restoring HIV-1 testing and interrupting active, ongoing, transmission.","journal":"The Journal of Infectious Diseases","year":2023,"id":383342,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7505,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1104322,"name":"Nathan Long","orcid":"0000-0002-0220-7318","position":1,"is_corresponding":false},{"id":444380,"name":"Matt Moeser","orcid":null,"position":2,"is_corresponding":false},{"id":552475,"name":"Collin S Hill","orcid":"0000-0003-3968-1862","position":3,"is_corresponding":false},{"id":341017,"name":"Erika Samoff","orcid":null,"position":4,"is_corresponding":false},{"id":340107,"name":"Victoria Mobley","orcid":"0000-0003-4702-4467","position":5,"is_corresponding":false},{"id":443173,"name":"Simon D. W. Frost","orcid":"0000-0002-5207-9879","position":6,"is_corresponding":false},{"id":648762,"name":"Cara J. Bayer","orcid":null,"position":7,"is_corresponding":false},{"id":427787,"name":"Elizabeth Kelly","orcid":"0000-0002-3722-8928","position":8,"is_corresponding":false},{"id":1150483,"name":"Annalea Greifinger","orcid":null,"position":9,"is_corresponding":false},{"id":1150153,"name":"Scott M. Shone","orcid":"0000-0001-8171-6331","position":10,"is_corresponding":false},{"id":1104493,"name":"William A. Glover","orcid":null,"position":11,"is_corresponding":false},{"id":36086,"name":"Michael Clark","orcid":"0000-0002-4762-5134","position":12,"is_corresponding":false},{"id":249713,"name":"Joseph J. Eron","orcid":"0000-0002-4938-0644","position":13,"is_corresponding":false},{"id":249712,"name":"Myron S. Cohen","orcid":"0000-0001-5917-9664","position":14,"is_corresponding":false},{"id":247475,"name":"Ronald Swanstrom","orcid":"0000-0001-7777-0773","position":15,"is_corresponding":false},{"id":438197,"name":"Ann M. Dennis","orcid":"0000-0003-0687-9661","position":16,"is_corresponding":false},{"id":416700,"name":"Shuntai Zhou","orcid":"0000-0002-8353-386X","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:17:25.158896Z","pmid":"37283544","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}