{"doi":"10.1093/infdis/jiad136","title":"Fluorescent and Bioluminescent Reporter Mouse-Adapted Ebola Viruses Maintain Pathogenicity and Can Be Visualized in Vivo","abstract":"Ebola virus (EBOV) causes lethal disease in humans but not in mice. Here, we generated recombinant mouse-adapted (MA) EBOVs, including 1 based on the previously reported serially adapted strain (rMA-EBOV), along with single-reporter rMA-EBOVs expressing either fluorescent (ZsGreen1 [ZsG]) or bioluminescent (nano-luciferase [nLuc]) reporters, and dual-reporter rMA-EBOVs expressing both ZsG and nLuc. No detriment to viral growth in vitro was seen with inclusion of MA-associated mutations or reporter proteins. In CD-1 mice, infection with MA-EBOV, rMA-EBOV, and single-reporter rMA-EBOVs conferred 100% lethality; infection with dual-reporter rMA-EBOV resulted in 73% lethality. Bioluminescent signal from rMA-EBOV expressing nLuc was detected in vivo and ex vivo using the IVIS Spectrum CT. Fluorescent signal from rMA-EBOV expressing ZsG was detected in situ using handheld blue-light transillumination and ex vivo through epi-illumination with the IVIS Spectrum CT. These data support the use of reporter MA-EBOV for studies of Ebola virus in animal disease models.","journal":"The Journal of Infectious Diseases","year":2023,"id":370068,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344999,"name":"Stephen R. Welch","orcid":"0000-0002-6905-8521","position":1,"is_corresponding":false},{"id":724696,"name":"Shilpi Jain","orcid":"0000-0002-5638-0298","position":2,"is_corresponding":false},{"id":786812,"name":"Teresa E. Sorvillo","orcid":"0000-0003-2943-4040","position":3,"is_corresponding":false},{"id":345001,"name":"JoAnn D. Coleman-McCray","orcid":"0000-0003-0396-2224","position":4,"is_corresponding":false},{"id":542501,"name":"Joel M. Montgomery","orcid":"0000-0003-0523-4431","position":5,"is_corresponding":false},{"id":345004,"name":"Christina F. Spiropoulou","orcid":"0000-0001-8406-3161","position":6,"is_corresponding":false},{"id":938945,"name":"César G. Albariño","orcid":"0000-0002-8013-1785","position":7,"is_corresponding":false},{"id":344997,"name":"Jessica R. Spengler","orcid":"0000-0002-5383-0513","position":8,"is_corresponding":false},{"id":316530,"name":"Katherine A. Davies","orcid":"0000-0002-4423-4664","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T01:15:37.094100Z","pmid":"37145895","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}