{"doi":"10.1093/infdis/jiad135","title":"De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection","abstract":"The emergence of novel variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need to investigate alternative approaches to prevent infection and treat patients with coronavirus disease 2019. Here, we report the preclinical efficacy of NL-CVX1, a de novo decoy that blocks virus entry into cells by binding with nanomolar affinity and high specificity to the receptor-binding domain of the SARS-CoV-2 spike protein. Using a transgenic mouse model of SARS-CoV-2 infection, we showed that a single prophylactic intranasal dose of NL-CVX1 conferred complete protection from severe disease following SARS-CoV-2 infection. Multiple therapeutic administrations of NL-CVX1 also protected mice from succumbing to infection. Finally, we showed that infected mice treated with NL-CVX1 developed both anti-SARS-CoV-2 antibodies and memory T cells and were protected against reinfection a month after treatment. Overall, these observations suggest NL-CVX1 is a promising therapeutic candidate for preventing and treating severe SARS-CoV-2 infections.","journal":"The Journal of Infectious Diseases","year":2023,"id":365624,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":469046,"name":"Cong Tang","orcid":"0000-0003-1661-6793","position":1,"is_corresponding":false},{"id":655556,"name":"Ana R. Coelho","orcid":"0000-0002-0965-7573","position":2,"is_corresponding":false},{"id":1121481,"name":"Carlos Labão‐Almeida","orcid":"0000-0002-7797-3797","position":3,"is_corresponding":false},{"id":1121482,"name":"Matthias M. Schneider","orcid":"0000-0002-1894-1859","position":4,"is_corresponding":false},{"id":1121907,"name":"Laurie Tatalick","orcid":null,"position":5,"is_corresponding":false},{"id":1121483,"name":"Pedro Ruivo","orcid":"0000-0002-5419-4790","position":6,"is_corresponding":false},{"id":1025110,"name":"Marta Pires de Miranda","orcid":"0000-0003-3733-4963","position":7,"is_corresponding":false},{"id":1121484,"name":"Andréia Gomes","orcid":"0000-0003-2605-2565","position":8,"is_corresponding":false},{"id":654637,"name":"Tânia Carvalho","orcid":"0000-0002-5283-5013","position":9,"is_corresponding":false},{"id":245054,"name":"Matthew J. Walker","orcid":"0000-0001-5541-9245","position":10,"is_corresponding":false},{"id":1121908,"name":"Hannes Ausserwoeger","orcid":null,"position":11,"is_corresponding":false},{"id":728248,"name":"J. Pedro Simas","orcid":"0000-0001-6982-9253","position":12,"is_corresponding":false},{"id":628734,"name":"Marc Veldhoen","orcid":"0000-0002-1478-9562","position":13,"is_corresponding":false},{"id":353384,"name":"Tuomas P. J. Knowles","orcid":"0000-0002-7879-0140","position":14,"is_corresponding":false},{"id":245072,"name":"Daniel‐Adriano Silva","orcid":"0000-0002-3195-9009","position":15,"is_corresponding":false},{"id":1121909,"name":"David Shoultz","orcid":null,"position":16,"is_corresponding":false},{"id":654638,"name":"Gonçalo J. L. Bernardes","orcid":"0000-0001-6594-8917","position":17,"is_corresponding":false},{"id":1025108,"name":"Maria Rebelo","orcid":"0000-0003-2715-7182","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:14:50.885797Z","pmid":"37279654","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}