{"doi":"10.1093/infdis/jiad001","title":"Development of a Corticosteroid-Immunosuppressed Mouse Model to Study the Pathogenesis and Therapy of Influenza-Associated Pulmonary Aspergillosis","abstract":"Influenza-associated pulmonary aspergillosis (IAPA) is a feared complication in patients with influenza tracheobronchitis, especially those receiving corticosteroids. Herein, we established a novel IAPA mouse model with low-inoculum Aspergillus infection and compared outcomes in mice with and without cortisone acetate (CA) immunosuppression. CA was an independent predictor of increased morbidity/mortality in mice with IAPA. Early antifungal treatment with liposomal amphotericin B was pivotal to improve IAPA outcomes in CA-immunosuppressed mice, even after prior antiviral therapy with oseltamivir. In summary, our model recapitulates key clinical features of IAPA and provides a robust preclinical platform to study the pathogenesis and treatment of IAPA.","journal":"The Journal of Infectious Diseases","year":2023,"id":345525,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297872,"name":"Jezreel Pantaleón García","orcid":"0000-0002-9647-2584","position":1,"is_corresponding":false},{"id":425409,"name":"Nathaniel D. Albert","orcid":null,"position":2,"is_corresponding":false},{"id":275261,"name":"Ying Jiang","orcid":"0000-0001-6381-1458","position":3,"is_corresponding":false},{"id":1085529,"name":"Keerthi Bhoda","orcid":null,"position":4,"is_corresponding":false},{"id":908470,"name":"Vikram V Kulkarni","orcid":null,"position":5,"is_corresponding":false},{"id":963505,"name":"Yongxing Wang","orcid":"0000-0001-9665-5383","position":6,"is_corresponding":false},{"id":24302,"name":"Thomas J. Walsh","orcid":"0000-0002-4142-8711","position":7,"is_corresponding":false},{"id":297875,"name":"Scott E. Evans","orcid":"0000-0003-4503-0644","position":8,"is_corresponding":false},{"id":95683,"name":"Dimitrios P. Kontoyiannis","orcid":"0000-0002-8051-2940","position":9,"is_corresponding":false},{"id":301203,"name":"Sebastian Wurster","orcid":"0000-0002-7784-7256","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T01:11:39.484741Z","pmid":"36611269","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}