{"doi":"10.1093/infdis/jiac498","title":"Upregulation of<i>PTPRC</i>and Interferon Response Pathways in HIV-1 Seroconverters Prior to Infection","abstract":"Human immunodeficiency virus 1 (HIV-1) exposed seronegative (HESN) individuals may have unique characteristics that alter susceptibility to HIV-1 infection. However, identifying truly exposed HESN is challenging. We utilized stored data and biospecimens from HIV-1 serodifferent couple cohorts, in which couples' HIV-1 exposures were quantified based on unprotected sex frequency and viral load of the partner with HIV-1. We compared peripheral blood gene expression between 15 HESN and 18 seroconverters prior to infection. We found PTPRC (encoding CD45 antigen) and interferon-response pathways had significantly higher expression among individuals who went on to become seropositive and thus may be a signature for increased acquisition risk.","journal":"The Journal of Infectious Diseases","year":2023,"id":365106,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1039303,"name":"François Lefebvre","orcid":"0000-0002-4440-7131","position":1,"is_corresponding":false},{"id":231145,"name":"Moses Joloba","orcid":"0000-0002-0334-9983","position":2,"is_corresponding":false},{"id":366534,"name":"Allan Ronald","orcid":"0000-0002-5746-3490","position":3,"is_corresponding":false},{"id":314444,"name":"Glenda Gray","orcid":"0000-0003-4649-1477","position":4,"is_corresponding":false},{"id":603465,"name":"Guy de Bruyn","orcid":"0000-0002-8028-4474","position":5,"is_corresponding":false},{"id":366536,"name":"James Kiarie","orcid":"0000-0003-4180-7858","position":6,"is_corresponding":false},{"id":299050,"name":"Connie Celum","orcid":"0000-0002-8813-3419","position":7,"is_corresponding":false},{"id":105516,"name":"Mark J. Cameron","orcid":"0000-0003-4768-4094","position":8,"is_corresponding":false},{"id":340294,"name":"Jairam R. Lingappa","orcid":"0000-0001-6191-9828","position":9,"is_corresponding":false},{"id":544218,"name":"Romel D. Mackelprang","orcid":"0000-0003-0308-4097","position":10,"is_corresponding":false},{"id":1120629,"name":"Yunqi Li","orcid":"0000-0002-8887-9691","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:14:46.760245Z","pmid":"36637125","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}