{"doi":"10.1093/infdis/jiac482","title":"Persistence of Immunogenicity of a Purified Inactivated Zika Virus Vaccine Candidate in Healthy Adults: 2 Years of Follow-up Compared With Natural Infection","abstract":"BACKGROUND: We report 2-year persistence of immune response to Takeda's prophylactic purified formalin-inactivated whole Zika virus vaccine candidate (TAK-426) compared with that observed after natural infection. METHODS: A randomized, observer-blind, placebo-controlled, dose-selection, phase 1 trial was conducted in 18-49-year-old adults at 9 centers (7 in the United States, 2 in Puerto Rico) from 13 November 2017 to 24 November 2020. Primary objectives were safety, tolerability, and immunogenicity of 3 increasing doses of TAK-426 administered as 2 doses 28 days apart to flavivirus (FV)-naive and FV-primed adults. Here, we report on safety and persistence of immunity up to 2 years after primary vaccination with 10-μg TAK-426, the highest dose, and compare neutralizing antibody responses with those observed after natural infection. RESULTS: TAK-426 at 10-μg had an acceptable safety profile in FV-naive and FV-primed adults up to 24 months after dose 2. Seropositivity for neutralizing antibodies was 100% at 1 year, and 93.8% and 76.2% at 2 years in FV-naive and FV-primed groups, respectively. TAK-426 responses were comparable in magnitude and kinetics with those elicited by natural Zika virus infection. CONCLUSIONS: These results support the further clinical development of TAK-426 for both FV-naive and FV-primed populations. CLINICAL TRIALS REGISTRATION: NCT03343626.","journal":"The Journal of Infectious Diseases","year":2022,"id":262704,"datarank":0.5291205703265369,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.12291304016120537,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.12291304016120537,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":10,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8533,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03343626"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":919044,"name":"Clemente Díaz","orcid":null,"position":1,"is_corresponding":false},{"id":419376,"name":"Francesco Nordio","orcid":null,"position":2,"is_corresponding":false},{"id":919045,"name":"Htay-Htay Han","orcid":null,"position":3,"is_corresponding":false},{"id":919046,"name":"Kelley J. Moss","orcid":null,"position":4,"is_corresponding":false},{"id":918579,"name":"Kelly Bohning","orcid":"0000-0002-1511-5594","position":5,"is_corresponding":false},{"id":626032,"name":"Pradeep Kumar","orcid":"0000-0002-0892-5425","position":6,"is_corresponding":false},{"id":918580,"name":"Mengya Liu","orcid":"0000-0002-8875-6907","position":7,"is_corresponding":false},{"id":372469,"name":"Hetal Patel","orcid":"0000-0002-5468-2591","position":8,"is_corresponding":false},{"id":919047,"name":"Filippo Pacciarini","orcid":null,"position":9,"is_corresponding":false},{"id":918581,"name":"Vincent Mwangi","orcid":"0009-0008-3710-5195","position":10,"is_corresponding":false},{"id":919048,"name":"Elke Walter","orcid":null,"position":11,"is_corresponding":false},{"id":150939,"name":"Tim D. Powell","orcid":null,"position":12,"is_corresponding":false},{"id":98392,"name":"Hana M. El Sahly","orcid":"0000-0003-0489-0074","position":13,"is_corresponding":false},{"id":919049,"name":"Whitney R. Baldwin","orcid":null,"position":14,"is_corresponding":false},{"id":919050,"name":"Joseph D. Santangelo","orcid":null,"position":15,"is_corresponding":false},{"id":94484,"name":"Evan J. Anderson","orcid":"0000-0002-1576-4420","position":16,"is_corresponding":false},{"id":919051,"name":"Gary Dubin","orcid":null,"position":17,"is_corresponding":false},{"id":918578,"name":"Camilo J. Acosta","orcid":"0000-0002-2313-3493","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:26:25.074177Z","pmid":"36484441","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}