{"doi":"10.1093/infdis/jiac314","title":"Dispensability of Ascorbic Acid Uptake and Utilization Encoded by <i>ulaABCD</i> for the Virulence of <i>Haemophilus ducreyi</i> in Humans","abstract":"Compared with wounded skin, ascorbic acid is enriched in pustules of humans experimentally infected with Haemophilus ducreyi. Compared with the broth-grown inocula, transcription of the H. ducreyi ulaABCD operon, which encodes genes for ascorbic acid uptake, is increased in pustules. We hypothesized that ascorbic acid uptake plays a role in H. ducreyi virulence. Five volunteers were infected with both H. ducreyi strain 35000HP and its isogenic ulaABCD deletion mutant at multiple sites; the papule and pustule formation rates of the mutant and parent strains were similar. Thus, ascorbic acid uptake is not essential for H. ducreyi virulence in humans.","journal":"The Journal of Infectious Diseases","year":2022,"id":288977,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":922083,"name":"Kate R. Fortney","orcid":null,"position":1,"is_corresponding":false},{"id":794141,"name":"Teresa A. Batteiger","orcid":"0000-0002-5097-1425","position":2,"is_corresponding":false},{"id":421451,"name":"Barry P. Katz","orcid":null,"position":3,"is_corresponding":false},{"id":342606,"name":"Stanley M. Spinola","orcid":"0000-0003-3435-9911","position":4,"is_corresponding":false},{"id":428625,"name":"Julie A. Brothwell","orcid":"0000-0002-5277-3692","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T00:30:18.766838Z","pmid":"35876728","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}