{"doi":"10.1093/infdis/jiac267","title":"HIV Treatment Outcomes in POP-UP: Drop-in HIV Primary Care Model for People Experiencing Homelessness","abstract":"BACKGROUND: People with HIV experiencing homelessness have low rates of viral suppression, driven by sociostructural barriers and traditional care system limitations. Informed by the capability-opportunity-motivation-behavior (COM-B) model and patient preference research, we developed POP-UP, an integrated drop-in (nonappointment-based) HIV clinic with wrap-around services for persons with housing instability and viral nonsuppression in San Francisco. METHODS: We report HIV viral suppression (VS; <200 copies/mL), care engagement, and mortality at 12 months postenrollment. We used logistic regression to determine participant characteristics associated with VS. RESULTS: We enrolled 112 patients with viral nonsuppression and housing instability: 52% experiencing street-homelessness, 100% with a substance use disorder, and 70% with mental health diagnoses. At 12 months postenrollment, 70% had ≥1 visit each 4-month period, although 59% had a 90-day care gap; 44% had VS, 24% had viral nonsuppression, 23% missing, and 9% died (6 overdose, 2 AIDS-associated, 2 other). No baseline characteristics were associated with VS. CONCLUSIONS: The POP-UP low-barrier HIV care model successfully reached and retained some of our clinic's highest-risk patients. It was associated with VS improvement from 0% at baseline to 44% at 12 months among people with housing instability. Care gaps and high mortality from overdose remain major challenges to achieving optimal HIV treatment outcomes in this population.","journal":"The Journal of Infectious Diseases","year":2022,"id":247030,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.941,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":497711,"name":"Elizabeth Imbert","orcid":"0000-0002-3060-3596","position":1,"is_corresponding":false},{"id":435846,"name":"Ayesha Appa","orcid":"0000-0002-4602-5954","position":2,"is_corresponding":false},{"id":374111,"name":"Jan Bing Del Rosario","orcid":"0000-0003-2753-8639","position":3,"is_corresponding":false},{"id":884390,"name":"Elizabeth Lynch","orcid":"0000-0001-8756-1051","position":4,"is_corresponding":false},{"id":184548,"name":"John Friend","orcid":null,"position":5,"is_corresponding":false},{"id":884391,"name":"Rodrigo Ávila","orcid":"0000-0001-8972-9663","position":6,"is_corresponding":false},{"id":498500,"name":"Angelo Clemenzi-Allen","orcid":null,"position":7,"is_corresponding":false},{"id":415733,"name":"Elise D. Riley","orcid":"0000-0001-5867-1155","position":8,"is_corresponding":false},{"id":241509,"name":"Monica Gandhi","orcid":"0000-0002-7025-1994","position":9,"is_corresponding":false},{"id":58746,"name":"Diane V. Havlir","orcid":"0000-0003-0761-3136","position":10,"is_corresponding":false},{"id":497710,"name":"Matthew D. Hickey","orcid":"0000-0001-8913-1602","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T00:23:53.369530Z","pmid":"35759251","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}