{"doi":"10.1093/infdis/jiac206","title":"Real-World Evidence of the Neutralizing Monoclonal Antibody Sotrovimab for Preventing Hospitalization and Mortality in COVID-19 Outpatients","abstract":"BACKGROUND: It is not known whether sotrovimab, a neutralizing monoclonal antibody (mAb) treatment authorized for early symptomatic coronavirus disease 2019 (COVID-19) patients, is also effective in preventing the progression of severe disease and mortality following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant infection. METHODS: In an observational cohort study of nonhospitalized adult patients with SARS-CoV-2 infection, 1 October 2021-11 December 2021, using electronic health records from a statewide health system plus state-level vaccine and mortality data, we used propensity matching to select 3 patients not receiving mAbs for each patient who received outpatient sotrovimab treatment. The primary outcome was 28-day hospitalization; secondary outcomes included mortality and severity of hospitalization. RESULTS: Of 10 036 patients with SARS-CoV-2 infection, 522 receiving sotrovimab were matched to 1563 not receiving mAbs. Compared to mAb-untreated patients, sotrovimab treatment was associated with a 63% decrease in the odds of all-cause hospitalization (raw rate 2.1% vs 5.7%; adjusted odds ratio [aOR], 0.37; 95% confidence interval [CI], .19-.66) and an 89% decrease in the odds of all-cause 28-day mortality (raw rate 0% vs 1.0%; aOR, 0.11; 95% CI, .0-.79), and may reduce respiratory disease severity among those hospitalized. CONCLUSIONS: Real-world evidence demonstrated sotrovimab effectiveness in reducing hospitalization and all-cause 28-day mortality among COVID-19 outpatients during the Delta variant phase.","journal":"The Journal of Infectious Diseases","year":2022,"id":238496,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":862342,"name":"Laurel Beaty","orcid":"0000-0001-8021-7872","position":1,"is_corresponding":false},{"id":49886,"name":"Tellen D. Bennett","orcid":"0000-0003-1483-4236","position":2,"is_corresponding":false},{"id":519059,"name":"Nichole E. Carlson","orcid":"0000-0003-0679-6663","position":3,"is_corresponding":false},{"id":862778,"name":"Christopher B. Davis","orcid":null,"position":4,"is_corresponding":false},{"id":298639,"name":"Bethany M. Kwan","orcid":"0000-0002-4013-5618","position":5,"is_corresponding":false},{"id":11318,"name":"David A Mayer","orcid":"0000-0002-6056-9771","position":6,"is_corresponding":false},{"id":460595,"name":"Toan C. Ong","orcid":"0000-0001-6787-1407","position":7,"is_corresponding":false},{"id":558539,"name":"Seth Russell","orcid":"0000-0002-2436-1367","position":8,"is_corresponding":false},{"id":862779,"name":"Jeffrey Steele","orcid":null,"position":9,"is_corresponding":false},{"id":770089,"name":"Adane F. Wogu","orcid":"0000-0002-6592-6512","position":10,"is_corresponding":false},{"id":562767,"name":"Matthew K. Wynia","orcid":"0000-0003-3307-069X","position":11,"is_corresponding":false},{"id":18475,"name":"Richard D. Zane","orcid":"0000-0003-2872-0141","position":12,"is_corresponding":false},{"id":105999,"name":"Adit A. Ginde","orcid":"0000-0003-2325-206X","position":13,"is_corresponding":false},{"id":604590,"name":"Neil R. Aggarwal","orcid":"0000-0002-0922-8824","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T00:22:26.932537Z","pmid":"35576581","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}