{"doi":"10.1093/infdis/jiac160","title":"Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis","abstract":"Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture-positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542-9188] vs 698 [218-4060] pg/mL, respectively; P = .004) and after (3650 [1214-3888] vs 720 [551-1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.","journal":"The Journal of Infectious Diseases","year":2022,"id":280389,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":406977,"name":"Farina Karim","orcid":"0000-0001-9698-016X","position":1,"is_corresponding":false},{"id":442724,"name":"Mohamed Y. S. Moosa","orcid":null,"position":2,"is_corresponding":false},{"id":822681,"name":"Shamala Moodley","orcid":"0000-0002-2041-2913","position":3,"is_corresponding":false},{"id":498499,"name":"Matilda Mazibuko","orcid":null,"position":4,"is_corresponding":false},{"id":497707,"name":"Karim Khan","orcid":"0000-0001-8689-9245","position":5,"is_corresponding":false},{"id":240257,"name":"Timothy R. Sterling","orcid":"0000-0002-4822-6979","position":6,"is_corresponding":false},{"id":428986,"name":"Yuri F. van der Heijden","orcid":"0000-0001-7631-9796","position":7,"is_corresponding":false},{"id":274995,"name":"Alison D. Grant","orcid":"0000-0002-2437-5195","position":8,"is_corresponding":false},{"id":266685,"name":"Paul Elkington","orcid":"0000-0003-0390-0613","position":9,"is_corresponding":false},{"id":274996,"name":"Alexander S. Pym","orcid":"0000-0002-6260-8180","position":10,"is_corresponding":false},{"id":104353,"name":"Alasdair Leslie","orcid":"0000-0003-2538-6467","position":11,"is_corresponding":false},{"id":266675,"name":"Naomi F. Walker","orcid":"0000-0002-3345-7694","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":null,"created_at":"2026-07-19T00:29:03.247347Z","pmid":"35510939","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}