{"doi":"10.1093/infdis/jiac138","title":"Functional Compartmentalization of Antibodies in the Central Nervous System During Chronic HIV Infection","abstract":"The central nervous system (CNS) has emerged as a critical HIV reservoir. Thus, interventions aimed at controlling and eliminating HIV must include CNS-targeted strategies. Given the inaccessibility of the brain, efforts have focused on cerebrospinal fluid (CSF), aimed at defining biomarkers of HIV-disease in the CNS, including HIV-specific antibodies. However, how antibodies traffic between the blood and CNS, and whether specific antibody profiles track with HIV-associated neurocognitive disorders (HAND) remains unclear. Here, we comprehensively profiled HIV-specific antibodies across plasma and CSF from 20 antiretroviral therapy (ART) naive or treated persons with HIV. CSF was populated by IgG1 and IgG3 antibodies, with reduced Fc-effector profiles. While ART improved plasma antibody functional coordination, CSF profiles were unaffected by ART and were unrelated to HAND severity. These data point to a functional sieving of antibodies across the blood-brain barrier, providing previously unappreciated insights for the development of next-generation therapeutics targeting the CNS reservoir.","journal":"The Journal of Infectious Diseases","year":2022,"id":263024,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":96647,"name":"Carolin Loos","orcid":"0000-0003-3680-0627","position":1,"is_corresponding":false},{"id":663368,"name":"Deniz Cizmeci","orcid":"0000-0003-3231-7726","position":2,"is_corresponding":false},{"id":690756,"name":"Nicholas E. Webb","orcid":"0000-0003-4370-553X","position":3,"is_corresponding":false},{"id":321856,"name":"Matthew J. Gorman","orcid":null,"position":4,"is_corresponding":false},{"id":354914,"name":"Evan Rossignol","orcid":null,"position":5,"is_corresponding":false},{"id":108386,"name":"Sally Shin","orcid":"0000-0002-9306-2264","position":6,"is_corresponding":false},{"id":628510,"name":"Dansu Yuan","orcid":"0000-0003-4815-7237","position":7,"is_corresponding":false},{"id":919431,"name":"Laura Fontana","orcid":"0000-0001-9517-6997","position":8,"is_corresponding":false},{"id":311025,"name":"Shibani S. Mukerji","orcid":"0000-0002-5677-6954","position":9,"is_corresponding":false},{"id":19320,"name":"Douglas A. Lauffenburger","orcid":"0000-0002-0050-989X","position":10,"is_corresponding":false},{"id":18100,"name":"Dana Gabuzda","orcid":"0000-0002-4964-5083","position":11,"is_corresponding":false},{"id":106757,"name":"Galit Alter","orcid":"0000-0002-7680-9215","position":12,"is_corresponding":false},{"id":900897,"name":"Marianna Spatola","orcid":"0000-0003-2548-0429","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:26:29.321923Z","pmid":"35417540","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}