{"doi":"10.1093/infdis/jiac134","title":"Breakthrough Gastrointestinal COVID-19 and Intrahost Evolution Consequent to Combination Monoclonal Antibody Prophylaxis","abstract":"Breakthrough gastrointestinal COVID-19 was observed after experimental SARS-CoV-2 upper mucosal infection in a rhesus macaque undergoing low-dose monoclonal antibody prophylaxis. High levels of viral RNA were detected in intestinal sites contrasting with minimal viral replication in upper respiratory mucosa. Sequencing of virus recovered from tissue in 3 gastrointestinal sites and rectal swab revealed loss of furin cleavage site deletions present in the inoculating virus stock and 2 amino acid changes in spike that were detected in 2 colon sites but not elsewhere, suggesting compartmentalized replication and intestinal viral evolution. This suggests suboptimal antiviral therapies promote viral sequestration in these anatomies.","journal":"The Journal of Infectious Diseases","year":2022,"id":292917,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463827,"name":"Lori A. Rowe","orcid":"0000-0003-3744-496X","position":1,"is_corresponding":false},{"id":259608,"name":"Kasi Russell‐Lodrigue","orcid":"0000-0003-3719-0779","position":2,"is_corresponding":false},{"id":259607,"name":"Lara Doyle‐Meyers","orcid":"0000-0003-0212-9548","position":3,"is_corresponding":false},{"id":259612,"name":"Nadia Golden","orcid":"0000-0003-4161-7181","position":4,"is_corresponding":false},{"id":618118,"name":"Skye Spencer","orcid":"0000-0001-9570-9634","position":5,"is_corresponding":false},{"id":829732,"name":"Nicole R. Chirichella","orcid":null,"position":6,"is_corresponding":false},{"id":259605,"name":"Robert V. Blair","orcid":"0000-0001-9616-9414","position":7,"is_corresponding":false},{"id":259617,"name":"Nicholas J. Maness","orcid":"0000-0002-9332-7891","position":8,"is_corresponding":false},{"id":218444,"name":"Chad J. Roy","orcid":"0000-0002-1710-6974","position":9,"is_corresponding":false},{"id":259610,"name":"Brandon J. Beddingfield","orcid":"0000-0002-9438-1304","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T00:30:50.076284Z","pmid":"35429402","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}