{"doi":"10.1093/infdis/jiac057","title":"Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.</jats:p>\n               </jats:sec>","journal":"The Journal of Infectious Diseases","year":2022,"id":596986,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":896837,"name":"Daniel Mukadi-Bamuleka","orcid":null,"position":1,"is_corresponding":false},{"id":896838,"name":"Junior Bulabula-Penge","orcid":null,"position":2,"is_corresponding":false},{"id":687012,"name":"Guillaume Thaurignac","orcid":"0000-0002-8679-0546","position":3,"is_corresponding":false},{"id":332883,"name":"François Edidi-Atani","orcid":null,"position":4,"is_corresponding":false},{"id":648730,"name":"Fabrice Mambu-Mbika","orcid":null,"position":5,"is_corresponding":false},{"id":1529131,"name":"Bernice Danga-Yema","orcid":null,"position":6,"is_corresponding":false},{"id":648729,"name":"Meris Matondo-Kuamfumu","orcid":null,"position":7,"is_corresponding":false},{"id":564679,"name":"Eddy Kinganda-Lusamaki","orcid":"0000-0001-9795-0165","position":8,"is_corresponding":false},{"id":565431,"name":"Nella Bisento","orcid":null,"position":9,"is_corresponding":false},{"id":1394504,"name":"Raphaël Lumembe-Numbi","orcid":null,"position":10,"is_corresponding":false},{"id":1395626,"name":"Gabriel Kabamba-Lungenyi","orcid":null,"position":11,"is_corresponding":false},{"id":1229062,"name":"Divine Kitsa-Mutsumbirwa","orcid":null,"position":12,"is_corresponding":false},{"id":1529139,"name":"Nelson Kambale-Sivihwa","orcid":null,"position":13,"is_corresponding":false},{"id":1529140,"name":"François Boillot","orcid":null,"position":14,"is_corresponding":false},{"id":1529141,"name":"Eric Delaporte","orcid":null,"position":15,"is_corresponding":false},{"id":896841,"name":"Placide Mbala-Kingebeni","orcid":null,"position":16,"is_corresponding":false},{"id":331223,"name":"Ahidjo Ayouba","orcid":"0000-0002-5081-1632","position":17,"is_corresponding":false},{"id":36871,"name":"Martine Peeters","orcid":"0000-0001-6738-8730","position":18,"is_corresponding":false},{"id":896849,"name":"Steve Ahuka-Mundeke","orcid":null,"position":19,"is_corresponding":false},{"id":636170,"name":"Antoine Nkuba-Ndaye","orcid":"0000-0003-2850-7498","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Added Value of an Anti-Ebola Serology for the Management of Clinically Suspected Ebola Virus Disease Patients Discharged as Negative in an Epidemic Context","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Survivors from Ebola virus disease (EVD) may be at the origin of EVD resurgence.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Simultaneous reactivity to at least 2 Ebola virus or Zaire ebolavirus (EBOV) antigens was detected in 11 of 488 (2.3%; 95% confidence interval [CI], 1.1–4.0) suspected EVD patients who were discharged as negative after 2 consecutive negative tests during the 10th Ebola outbreak in the Democratic Republic of the Congo.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>After extrapolating the total number of individuals discharged as negative during the entire outbreak, we estimated a total of 1314 additional missed Ebola cases.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>These findings emphasize the usefulness of an EBOV serology analysis and the importance of extending epidemic surveillance to clinically suspected cases who were discharged as negative.</jats:p>\n               </jats:sec>","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35176762","pmcid":"PMC9400424","openalex_id":"https://openalex.org/W4213036694","authors":[],"funders":[{"funder_name":"European and Developing Countries Clinical Trials Partnership","grant_id":"RIA2018EF-2087","title":null}],"total_grants":1,"fwci":1.0621,"citation_percentile":0.76917405,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":7},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"bronze","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","oa_locations":[{"url":"https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac057/43051796/jiac057.pdf","host_type":"journal"},{"url":"https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiac057/43051796/jiac057.pdf","host_type":"publisher"},{"url":"https://academic.oup.com/jid/article-pdf/226/2/352/45507897/jiac057.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1093/infdis/jiac057","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35176762","host_type":"repository"},{"url":"https://hal.science/hal-05540417","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9400424","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9400424","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9400424?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Viral Infections and Outbreaks Research","Disaster Response and Management","COVID-19 Digital Contact Tracing","Democratic Republic of the Congo","Disease Outbreaks","Ebolavirus","Epidemics","Hemorrhagic Fever, Ebola","Humans","Patient Discharge"],"mesh_terms":["Disease Outbreaks","Humans","Patient Discharge","Democratic Republic of the Congo","Hemorrhagic Fever, Ebola","Ebolavirus","Epidemics"],"keywords":["Ebola virus","Ebolavirus","Outbreak","Context (archaeology)","Serology","Medicine","Ebola Hemorrhagic Fever","Sierra leone","Disease","Virology","Immunology","Internal medicine","Biology","Antibody","Ebola","Drc","Ituri","North-kivu"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:54:25.106589Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}