{"doi":"10.1093/infdis/jiac047","title":"Cytomegalovirus Viremia Predicts Postdischarge Mortality in Kenyan HIV-Exposed Uninfected Children","abstract":"BACKGROUND: Cytomegalovirus (CMV) viremia is associated with mortality in severely ill immunocompetent adults and hospitalized children with HIV (CWH). We measured CMV viremia in HIV-exposed and -unexposed Kenyan children aged 1-59 months discharged from hospital and determined its relationship with postdischarge mortality. METHODS: CMV DNA levels were measured in plasma from 1024 children (97 of which were HIV exposed uninfected [HEU], and 15 CWH). Poisson and Cox proportional hazards regression models were used to identify correlates of CMV viremia ≥ 1000 IU/mL and estimate associations with 6-month mortality, respectively. RESULTS: CMV viremia was detected in 31% of children, with levels ≥ 1000 IU/mL in 5.8%. HIV infection, age < 2 years, breastfeeding, and midupper arm circumference < 12.5 cm were associated with CMV viremia ≥ 1000 IU/mL. Among HEU children, CMV ≥ 1000 IU/mL (hazard ratio [HR] = 32.0; 95% confidence interval [CI], 2.9-354.0; P = .005) and each 1-log increase in CMV viral load (HR = 5.04; 95% CI, 1.7-14.6; P = .003) were associated with increased risk of mortality. CMV viremia was not significantly associated with mortality in HIV-unexposed children. CONCLUSIONS: CMV levels at hospital postdischarge predict increased risk of 6-month mortality in Kenyan HEU children. CMV suppression may be a novel target to reduce mortality in HEU children. CLINICAL TRIAL REGISTRATION: NCT02414399.","journal":"The Journal of Infectious Diseases","year":2022,"id":273671,"datarank":0.5225493289531297,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.16286503803337402,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.16286503803337402,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":7,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02414399"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":407673,"name":"Benson Singa","orcid":"0000-0002-6605-324X","position":1,"is_corresponding":false},{"id":301546,"name":"Meei‐Li Huang","orcid":"0000-0003-2058-2776","position":2,"is_corresponding":false},{"id":233054,"name":"Lasata Shrestha","orcid":"0000-0002-9760-7348","position":3,"is_corresponding":false},{"id":941677,"name":"Vanessa Li","orcid":null,"position":4,"is_corresponding":false},{"id":873989,"name":"Hannah E Atlas","orcid":"0000-0003-1932-2563","position":5,"is_corresponding":false},{"id":874513,"name":"Mame M. Diakhate","orcid":null,"position":6,"is_corresponding":false},{"id":515243,"name":"Rebecca L Brander","orcid":"0000-0002-6156-0373","position":7,"is_corresponding":false},{"id":682767,"name":"Liru Meshak","orcid":null,"position":8,"is_corresponding":false},{"id":682768,"name":"George Bogonko","orcid":null,"position":9,"is_corresponding":false},{"id":681986,"name":"Kirkby D. Tickell","orcid":"0000-0002-4108-1236","position":10,"is_corresponding":false},{"id":412207,"name":"Christine J. McGrath","orcid":"0000-0003-3396-0350","position":11,"is_corresponding":false},{"id":941678,"name":"Irine M Machuara","orcid":null,"position":12,"is_corresponding":false},{"id":874512,"name":"Derrick O Ounga","orcid":null,"position":13,"is_corresponding":false},{"id":298911,"name":"James A. Berkley","orcid":"0000-0002-1236-849X","position":14,"is_corresponding":false},{"id":407491,"name":"Barbra A. Richardson","orcid":"0000-0001-9564-1828","position":15,"is_corresponding":false},{"id":299048,"name":"Grace John‐Stewart","orcid":"0000-0002-4301-1573","position":16,"is_corresponding":false},{"id":61413,"name":"Judd L. Walson","orcid":"0000-0003-4836-720X","position":17,"is_corresponding":false},{"id":941679,"name":"Jennifer Slyker","orcid":null,"position":18,"is_corresponding":false},{"id":515245,"name":"Patricia B. Pavlinac","orcid":"0000-0002-0051-9131","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T00:28:03.504676Z","pmid":"35152295","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}