{"doi":"10.1093/infdis/jiac028","title":"Lassa Virus Replicon Particle Vaccine Protects Strain 13/N Guinea Pigs Against Challenge With Geographically and Genetically Diverse Viral Strains","abstract":"Lassa virus (LASV) causes mild to severe hemorrhagic fever disease in humans. Strain 13/N guinea pigs are highly susceptible to infection with LASV strain Josiah (clade IV), providing a critical model system for therapeutics and vaccine development. To develop additional models of disease, we detail the clinical course in guinea pigs infected with 5 geographically and genetically diverse LASV strains. Two of the developed models (LASV clades II and III) were then used to evaluate efficacy of a virus replicon particle vaccine against heterologous LASV challenge, demonstrating complete protection against clinical disease after a single vaccination dose.","journal":"The Journal of Infectious Diseases","year":2022,"id":272406,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":445521,"name":"Markus H. Kainulainen","orcid":"0000-0003-2492-1210","position":1,"is_corresponding":false},{"id":344999,"name":"Stephen R. Welch","orcid":"0000-0002-6905-8521","position":2,"is_corresponding":false},{"id":939480,"name":"JoAnn D Coleman-McCray","orcid":null,"position":3,"is_corresponding":false},{"id":345000,"name":"Jessica R. Harmon","orcid":"0000-0001-6051-0254","position":4,"is_corresponding":false},{"id":939481,"name":"Jillian A. Condrey","orcid":null,"position":5,"is_corresponding":false},{"id":304506,"name":"Florine E. M. Scholte","orcid":"0000-0003-2110-3087","position":6,"is_corresponding":false},{"id":345002,"name":"Stuart T. Nichol","orcid":"0000-0002-7173-5093","position":7,"is_corresponding":false},{"id":542501,"name":"Joel M. Montgomery","orcid":"0000-0003-0523-4431","position":8,"is_corresponding":false},{"id":938945,"name":"César G. Albariño","orcid":"0000-0002-8013-1785","position":9,"is_corresponding":false},{"id":345004,"name":"Christina F. Spiropoulou","orcid":"0000-0001-8406-3161","position":10,"is_corresponding":false},{"id":344997,"name":"Jessica R. Spengler","orcid":"0000-0002-5383-0513","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T00:27:47.926496Z","pmid":"35099012","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}