{"doi":"10.1093/infdis/jiab569","title":"Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals","abstract":"Individuals on immunosuppressive (IS) therapy have increased mortality from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and delayed viral clearance may lead to new viral variants. IS therapy reduces antibody responses following coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccination; however, a comprehensive assessment of vaccine immunogenicity is lacking. Here we show that IS therapy reduced neutralizing, binding, and nonneutralizing antibody functions in addition to CD4 and CD8 T-cell interferon-γ responses following COVID-19 mRNA vaccination compared to immunocompetent individuals. Moreover, IS therapy reduced cross-reactivity against SARS-CoV-2 variants. These data suggest that the standard COVID-19 mRNA vaccine regimens will likely not provide optimal protection in immunocompromised individuals.","journal":"The Journal of Infectious Diseases","year":2021,"id":180766,"datarank":1.2814865234450687,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.847930759760644,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.847930759760644,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":14,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106716,"name":"Jingyou Yu","orcid":"0000-0002-0775-6623","position":1,"is_corresponding":false},{"id":106719,"name":"Katherine McMahan","orcid":"0000-0002-3933-0539","position":2,"is_corresponding":false},{"id":218111,"name":"Jinyan Liu","orcid":"0000-0003-0504-2181","position":3,"is_corresponding":false},{"id":106723,"name":"Caroline Atyeo","orcid":"0000-0002-7489-0232","position":4,"is_corresponding":false},{"id":346718,"name":"Jessica L. Ansel","orcid":null,"position":5,"is_corresponding":false},{"id":730286,"name":"Zachary Fricker","orcid":"0000-0001-5596-864X","position":6,"is_corresponding":false},{"id":730287,"name":"Martha Pavlakis","orcid":"0000-0003-1032-0801","position":7,"is_corresponding":false},{"id":730288,"name":"Michael P. Curry","orcid":"0000-0003-2110-3503","position":8,"is_corresponding":false},{"id":106747,"name":"Catherine Jacob-Dolan","orcid":"0000-0001-6641-0342","position":9,"is_corresponding":false},{"id":640637,"name":"Het Patel","orcid":"0000-0001-5321-9178","position":10,"is_corresponding":false},{"id":630510,"name":"Daniel Sellers","orcid":"0000-0002-8815-9459","position":11,"is_corresponding":false},{"id":630511,"name":"Julia Barrett","orcid":"0000-0002-5857-3632","position":12,"is_corresponding":false},{"id":730289,"name":"Marjorie Rowe","orcid":"0000-0002-3562-5567","position":13,"is_corresponding":false},{"id":730290,"name":"Kunza Ahmad","orcid":"0000-0001-9640-1498","position":14,"is_corresponding":false},{"id":634469,"name":"Annika Gompers","orcid":"0000-0002-2591-3477","position":15,"is_corresponding":false},{"id":671432,"name":"Ricardo Aguayo","orcid":null,"position":16,"is_corresponding":false},{"id":106518,"name":"Abishek Chandrashekar","orcid":"0000-0001-7821-5552","position":17,"is_corresponding":false},{"id":106757,"name":"Galit Alter","orcid":"0000-0002-7680-9215","position":18,"is_corresponding":false},{"id":326033,"name":"Michele R. Hacker","orcid":"0000-0003-0217-9991","position":19,"is_corresponding":false},{"id":106527,"name":"Dan H. Barouch","orcid":"0000-0001-5127-4659","position":20,"is_corresponding":false},{"id":656981,"name":"Ai‐ris Y. Collier","orcid":"0000-0002-8539-3960","position":0,"is_corresponding":true}],"reference_count":13,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:47:57.268805Z","pmid":"34792136","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}