{"doi":"10.1093/infdis/jiab565","title":"Genomic Characterization of Group A Streptococci Causing Pharyngitis and Invasive Disease in Colorado, USA, June 2016– April 2017","abstract":"BACKGROUND: The genomic features and transmission link of circulating Group A Streptococcus (GAS) strains causing different disease types, such as pharyngitis and invasive disease, are not well understood. METHODS: We used whole-genome sequencing to characterize GAS isolates recovered from persons with pharyngitis and invasive disease in the Denver metropolitan area from June 2016 to April 2017. RESULTS: The GAS isolates were cultured from 236 invasive and 417 pharyngitis infections. Whole-genome sequencing identified 34 emm types. Compared with pharyngitis isolates, invasive isolates were more likely to carry the erm family genes (23% vs 7.4%, P<.001), which confer resistance to erythromycin and clindamycin (including inducible resistance), and covS gene inactivation (7% vs 0.5%, P<.001). Whole-genome sequencing identified 97 genomic clusters (433 isolates; 2-65 isolates per cluster) that consisted of genomically closely related isolates (median single-nucleotide polymorphism=3 [interquartile range, 1-4] within cluster). Thirty genomic clusters (200 isolates; 31% of all isolates) contained both pharyngitis and invasive isolates and were found in 11 emm types. CONCLUSIONS: In the Denver metropolitan population, mixed disease types were commonly seen in clusters of closely related isolates, indicative of overlapping transmission networks. Antibiotic-resistance and covS inactivation was disproportionally associated with invasive disease.","journal":"The Journal of Infectious Diseases","year":2021,"id":175877,"datarank":0.7149536768499939,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.24462954446062138,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.24462954446062138,"corpus_percentile":71.94244604316546,"corpus_rank":3628,"citation_count":22,"citer_count":17,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5912,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":369319,"name":"Samuel R. Dominguez","orcid":"0000-0002-6707-5088","position":1,"is_corresponding":false},{"id":356548,"name":"Srinivas Nanduri","orcid":"0000-0003-0681-2790","position":2,"is_corresponding":false},{"id":283514,"name":"Joy Rivers","orcid":null,"position":3,"is_corresponding":false},{"id":283513,"name":"Saundra Mathis","orcid":null,"position":4,"is_corresponding":false},{"id":281654,"name":"Zhongya Li","orcid":"0000-0003-1247-2059","position":5,"is_corresponding":false},{"id":228835,"name":"Lesley McGee","orcid":"0000-0001-8214-921X","position":6,"is_corresponding":false},{"id":281653,"name":"Sopio Chochua","orcid":"0000-0001-8222-7353","position":7,"is_corresponding":false},{"id":281655,"name":"Benjamin J. Metcalf","orcid":"0000-0002-9628-2051","position":8,"is_corresponding":false},{"id":314166,"name":"Chris Van Beneden","orcid":"0000-0002-6250-9238","position":9,"is_corresponding":false},{"id":281658,"name":"Bernard Beall","orcid":"0000-0001-5315-1070","position":10,"is_corresponding":false},{"id":397347,"name":"Lisa A. Miller","orcid":"0000-0001-7557-1316","position":11,"is_corresponding":false},{"id":356547,"name":"Yuan Li","orcid":"0000-0003-3118-1070","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:47:19.591542Z","pmid":"34788828","pmcid":"PMC9125432","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}